1. Basic Product Profile
- Full IUPAC Name: 8-Methyl-8-azabicyclo[3.2.1]octan-3-one
- Aliases: 3-Tropinone, 8-Methylnorgranatanin-3-one
- CAS Number: 532-24-1
- EINECS: 208-529-7
- Molecular Formula: C8H13NO
- Molecular Weight: 139.20
- Chemical Classification: Chiral tropane pharmaceutical intermediate, bicyclic amine ketone building block, alkaloid synthetic precursor
- Core Advantages
Classic bicyclic tropane skeleton compound, key core intermediate for synthesizing atropine, scopolamine, anisodamine and other anticholinergic APIs. Simple derivatization via reduction, alkylation and esterification reactions, high purity grades meet pharmaceutical synthesis standards, widely adopted in chiral drug R&D and bulk drug production lines.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White to off-white crystalline solid
- Odor: Faint amine characteristic odor
- Solubility: Freely soluble in water, methanol, ethanol, dichloromethane; slightly soluble in ethyl acetate; insoluble in aliphatic alkanes
- Melting Point: 40–44 °C
- Boiling Point: 233–234 °C
- Hygroscopy: Slightly hygroscopic under high humidity atmosphere
- Basicity: Tertiary amine ring exhibits weak alkaline property
2.2 Chemical Properties
- Bicyclic Tertiary Amine & Ketone Dual Function: Ketone group undergoes reduction to tropine/pseudotropine; tertiary amine can form salts with inorganic acids
- Chiral Derivatization: Carbonyl asymmetric reduction generates single stereoisomer tropine, core precursor for tropane alkaloid APIs
- Acid & Alkali Stability: Stable under neutral and weak alkaline conditions; concentrated strong acid triggers ring opening degradation under heating
- Photostability: Avoid long-term intense UV irradiation to prevent slight discoloration
- Compatibility: Compatible with common organic solvents and neutral synthetic reagents; incompatible with strong oxidants and concentrated mineral acids at high temperature
3. Main Application Fields
3.1 Pharmaceutical Chiral Intermediate (Core Usage)
Key synthetic precursor for anticholinergic active pharmaceutical ingredients including atropine, scopolamine, anisodamine, ipratropium bromide; used for preparing gastrointestinal spasmolytic, anti-motion sickness and respiratory bronchodilator drugs.
3.2 Organic Synthetic Research Reagent
Standard tropane scaffold reference compound for alkaloid total synthesis research, substrate for asymmetric reduction and chiral catalysis experiments in university organic chemistry laboratories.
3.3 Fine Chemical Building Block
Raw material for developing novel tropane-type cholinergic receptor antagonists, applied in compound library construction for central nervous system drug screening.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 532-24-1 |
| Molecular Formula | C8H13NO |
| Molecular Weight | 139.20 |
| Appearance | White to off-white crystalline solid |
| Melting Range | 40–44 °C |
| HPLC Chemical Purity | Synthesis Grade ≥99.0% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined nitrogen-sealed fiber drum |
| Sample Package | 10g / 100g / 1kg sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate humid air, strong light, oxidants and concentrated acid substances |
| Transportation Rule | General pharmaceutical synthetic intermediate, non-hazardous goods; light-proof waterproof packaging mandatory during transit |
| Shelf Life | 24 months under intact nitrogen-sealed light-proof packaging |
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