The material is white to pale yellow crystalline solid. Purity detected by HPLC is not less than 98.0%. Water content is controlled within 0.5%. Residue on ignition is no more than 0.1%. Heavy metals content is less than 10 ppm. No obvious miscellaneous peaks in liquid phase chromatogram, all technical indicators conform to pharmaceutical intermediate grade standard.
Methyl 3-bromo-2-pyridinecarboxylate is an important halogenated pyridine heterocyclic building block. It contains reactive bromine atom and ester group on the pyridine ring, which can be used for Suzuki coupling, Heck reaction, nucleophilic substitution and hydrolysis reaction.
It is widely used as key intermediate in synthesis of anti-cancer drugs, anti-inflammatory drugs, kinase inhibitors and central nervous system related small molecule compounds. The ester group can be hydrolyzed to carboxylic acid or reduced to alcohol for further structural derivation, and it is also commonly used for medicinal chemistry compound library construction and SAR research.
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