The product is colorless to pale yellow liquid or solid. Purity by GC/HPLC is not less than 98.0%. Water content ≤ 0.5%. Residue on ignition ≤ 0.1%. Heavy metals less than 10 ppm. Chromatogram shows no obvious impurity peaks, all parameters meet pharmaceutical and fine chemical intermediate grade requirements.
4-Bromo-2-(trifluoromethyl)pyridine is a key fluorinated pyridine building block in medicinal chemistry and organic synthesis. The reactive bromine site can undergo Suzuki, Heck, Sonogashira and Buchwald-Hartwig coupling reactions for molecular structural modification.
