The product appears as colorless to pale yellow transparent liquid.
Purity analyzed by GC is not less than 98.0%.
Water content is controlled within 0.5%.
Residue on ignition is not more than 0.1%.
Heavy metals content is lower than 10 ppm.
Chromatogram shows no obvious impurity peaks, all specifications comply with pharmaceutical and fine chemical intermediate grade standards.
2-Chloro-5-(trifluoromethyl)pyridine is an important fluorinated pyridine heterocyclic building block in organic synthesis and medicinal chemistry.
The chlorine atom on the pyridine ring can participate in nucleophilic substitution, Suzuki coupling, Buchwald-Hartwig amination and other cross-coupling reactions for structural modification.
The trifluoromethyl group can significantly improve lipophilicity, chemical stability and metabolic stability of target molecules.
It is widely used as key intermediate for the synthesis of kinase inhibitors, anticancer drugs, anti-inflammatory agents, central nervous system drugs and agrochemicals.
It is also commonly applied in pharmaceutical compound library construction and structure-activity relationship research for new drug development.
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