The product is white to off-white crystalline solid.
Purity tested by HPLC is not less than 98.0%.
Water content is no more than 0.5%.
Residue on ignition is not more than 0.1%.
Heavy metals content is less than 10 ppm.
No obvious impurity peaks appear in chromatogram, all indexes meet pharmaceutical intermediate grade standard.
2-Bromo-5-chloropyridine is an important dihalogenated pyridine heterocyclic building block.
It contains both bromine and chlorine reactive sites on the pyridine ring for selective coupling reaction.
It can be used for Suzuki, Heck, Sonogashira and Buchwald-Hartwig cross-coupling reactions.
Widely applied as key intermediate in synthesis of kinase inhibitors, anticancer drugs, anti-inflammatory and CNS medicinal compounds.
Also used for medicinal chemistry compound library construction and structure-activity relationship research.
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