The product is white to off-white crystalline powder.
Purity tested by HPLC or GC is not less than 98.0%.
Water content is controlled within 0.5%.
Residue on ignition is not more than 0.1%.
Heavy metals content is less than 10 ppm.
Chromatogram has no obvious impurity peaks, all indexes meet pharmaceutical intermediate grade requirements.
2-Bromo-5-(trifluoromethyl)pyridine is a high-value fluorinated halogenated pyridine building block.
The bromine atom at pyridine ring can undergo Suzuki coupling, Heck reaction, Sonogashira reaction and Buchwald-Hartwig amination for structural derivatization.
The trifluoromethyl group can improve lipophilicity, chemical stability and metabolic stability of bioactive molecules.
It is widely used as key intermediate for synthesis of kinase inhibitors, anticancer drugs, anti-inflammatory agents and central nervous system drugs.
It is also commonly used in medicinal chemistry compound library construction, structure-activity relationship research and agrochemical intermediate development.
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