The product is white to off-white crystalline solid.
Purity detected by HPLC is not less than 98.0%.
Water content is controlled within 0.5%.
Residue on ignition is not more than 0.1%.
Heavy metals content is lower than 10 ppm.
No obvious impurity peaks in chromatogram, all specifications meet pharmaceutical intermediate grade requirements.
3-Bromo-5-methylpyridine is an important substituted bromopyridine heterocyclic building block.
It possesses active bromine functional group on pyridine ring, available for nucleophilic substitution and various cross-coupling reactions.
It can be used for Suzuki, Heck, Sonogashira and Buchwald-Hartwig amination reactions for molecular structural modification.
It is widely applied as key intermediate in the synthesis of kinase inhibitors, anticancer agents, anti-inflammatory drugs and central nervous system therapeutic compounds.
It is also commonly used for medicinal chemistry compound library construction and structure-activity relationship research in new drug development.
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