The product is white to off-white crystalline solid.
Purity tested by HPLC or GC is not less than 98.0%.
Water content is no more than 0.5%.
Residue on ignition is not more than 0.1%.
Heavy metals content is less than 10 ppm.
No obvious impurity peaks appear in chromatogram, all quality indexes conform to pharmaceutical intermediate grade standard.
4-Bromo-2-methylpyridine is a valuable substituted bromopyridine heterocyclic building block.
The bromine atom at 4-position of pyridine ring has good reaction activity for nucleophilic substitution.
It can undergo Suzuki coupling, Heck reaction, Sonogashira and Buchwald-Hartwig cross-coupling reactions.
It is widely used as key intermediate for synthesizing kinase inhibitors, anticancer drugs, anti-inflammatory agents and CNS medicinal molecules.
Also applied in medicinal chemistry compound library construction and structure-activity relationship research, as well as agrochemical intermediate synthesis.
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