Assay (GC/HPLC)≥95.0% (industrial grade); ≥97.0% (reagent grade)
AppearanceColorless to light yellow liquid
Density (25 °C)1.404–1.408 g/mL (lit.)
Refractive Index (20 °C)1.5460–1.5480 (lit.)
Melting Point-16 °C to -14 °C
Flash Point≥105 °C
Loss on Drying (Water Content)≤0.3%Residue on Ignition≤0.1%
Heavy Metals (Pb)≤10 ppm
Impurities Single impurity ≤0.5%, total impurities ≤2.0% (for ≥95.0% purity); single impurity ≤0.2%, total impurities ≤1.0% (for ≥97.0% purity)
Identification Consistent with the standard (IR/GC)
4. Main Applications (Detailed)
4-Bromobenzyl Methyl Ether (CAS 1515-88-4) is an important brominated aromatic ether compound, featuring a bromine atom and a methoxymethyl group on the benzene ring. Its unique molecular structure endows it with good reactivity, making it widely used as an intermediate in organic synthesis, pharmaceutical research, fine chemical production, and laboratory research.
4.1 Organic Synthesis Intermediate
As a key building block in organic synthesis, it is mainly used for the preparation of various aromatic derivatives through substitution, coupling, and oxidation reactions. The bromine atom on the benzene ring is highly reactive and can undergo Suzuki coupling, Heck coupling, and other cross-coupling reactions with organometallic compounds (such as organoboron, organozinc compounds) to introduce various functional groups. The methoxymethyl group (-CH?OCH?) can be further modified (e.g., hydrolysis, oxidation) to obtain benzyl alcohol, benzaldehyde, and other derivatives, which are important intermediates for the synthesis of complex organic molecules.
4.2 Pharmaceutical and Fine Chemical Intermediates
It serves as an important intermediate in the synthesis of pharmaceutical compounds, including antibacterial, antiviral, and anti-tumor drugs. Its brominated aromatic structure can be modified to synthesize drug molecules with specific biological activities, such as adjusting the lipophilicity and bioavailability of drugs. In the fine chemical industry, it is used in the production of specialty chemicals, such as organic catalysts, fragrance intermediates, and dye precursors. The methoxymethyl group in its structure can enhance the stability and solubility of target products, improving their application performance.
4.3 Laboratory Research Reagent
In scientific research, it is widely used as a research reagent in organic chemistry and pharmaceutical chemistry laboratories. It is utilized in the development of new synthetic methodologies, the study of reaction mechanisms (such as coupling reactions), and the synthesis of new organic compounds. It is also used as a standard substance for analytical detection (such as GC and HPLC) to verify the accuracy of detection methods and ensure the quality of experimental materials.
4.4 Other Applications
It is used in the synthesis of agrochemicals, such as herbicides and fungicides, to enhance their biological activity and stability. Additionally, it is used in the production of chemical reagents and electronic materials, playing an important role in the fields of chemical analysis and electronic manufacturing. It can also be used as a raw material for the synthesis of functional polymers, improving the thermal stability and mechanical properties of polymers.
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