Assay (GC/HPLC)≥98.0% (reagent grade); ≥99.0% (industrial grade); ≥99.5% (high-purity grade)
Appearance Clear colorless liquid
Density (25 °C)1.368–1.372 g/mL
Refractive Index (20 °C)1.379–1.481
Melting Point-36 °C to -34 °C
Flash Point 25–27 °C
Loss on Drying (Water Content)≤0.3%
Residue on Ignition≤0.1%
Heavy Metals (Pb)≤10 ppm
Impurities Single impurity ≤0.2%, total impurities ≤1.0% (for ≥98.0% purity); single impurity ≤0.1%, total impurities ≤0.5% (for ≥99.0% purity)
Identification Consistent with the standard (IR/GC)
4. Main Applications (Detailed)
1,3-Bis(trifluoromethyl)benzene (CAS 402-31-3), also known as hexafluoro-m-xylene, is an important fluorinated aromatic compound with two trifluoromethyl groups (-CF?) on the meta-position of the benzene ring. Its unique fluorinated structure endows it with excellent chemical stability, lipophilicity, and low polarity, making it widely used as an intermediate in organic synthesis, pharmaceuticals, pesticides, fine chemicals, and other fields.
4.1 Pharmaceutical and Pesticide Intermediates
It is a key intermediate in the synthesis of pharmaceutical and pesticide products. The trifluoromethyl groups in its structure can enhance the bioavailability, metabolic stability, and biological activity of target molecules, making it an important raw material for the synthesis of antibacterial, antiviral, anti-tumor drugs, and high-efficiency pesticides. It is widely used in the research and development of new drugs and pesticides, providing a stable molecular skeleton for the modification of drug and pesticide structures.
4.2 Organic Synthesis Intermediate
As an important building block in organic synthesis, it is used for the preparation of various fluorinated aromatic derivatives through substitution, oxidation, and coupling reactions. The benzene ring can undergo electrophilic substitution reactions, and the trifluoromethyl groups can be further modified to introduce other functional groups, which are widely used in the synthesis of complex organic molecules, fluorinated dyes, and specialty chemicals. It can also be used as a solvent in organic synthesis reactions due to its good solubility in common organic solvents.
4.3 Fine Chemical and Material Industry
In the fine chemical industry, it is used in the production of fluorinated resins, phenol-based dye intermediates, and specialty additives. The fluorinated groups in its structure can improve the thermal stability, chemical resistance, and hydrophobicity of materials, making it suitable for the preparation of high-performance fluorinated materials. In addition, it is used in the production of electronic materials and specialty coatings, playing an important role in the fields of electronic manufacturing and material science.
4.4 Solvent Applications
It serves as a high-performance solvent in the photography and clock industries, due to its low polarity, good solubility, and chemical stability. It can dissolve a variety of organic compounds and is not easy to react with other substances, making it suitable for use as a solvent in precision manufacturing processes such as photography and clock assembly.
4.5 Laboratory Research Reagent
In scientific research, it is used as a research reagent in organic chemistry, fluorine chemistry, and pharmaceutical chemistry laboratories. It is utilized in the development of new synthetic methodologies, the study of fluorinated compound properties, and the synthesis of new fluorinated materials. It is also used as a standard substance for analytical detection (such as GC and HPLC) to verify the accuracy of detection methods.
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