- Purity (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder
- Moisture: ≤0.5%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
- Melting Point: 275–280 °C (decomp.)
Applications
2-Chloro-4-hydroxyquinoline is a critical quinoline heterocyclic intermediate. It features a reactive chloro substituent and a hydroxyl group, enabling nucleophilic substitution, coupling reactions, and condensation reactions. It serves as a key building block for synthesizing anti-inflammatory, antibacterial, and antitumor pharmaceutical intermediates, as well as kinase inhibitors and G-protein coupled receptor (GPCR) modulators. It is also widely used in developing agrochemicals such as fungicides and herbicides, and as a research tool in chemical biology and medicinal chemistry for exploring structure-activity relationships (SAR) of bioactive molecules.
Safety Information
May be harmful if swallowed, inhaled, or absorbed through skin. Causes eye, skin, and respiratory tract irritation. Avoid inhalation of dust and contact with skin and eyes. Handle in a well-ventilated fume hood with nitrile gloves, safety goggles, and a dust mask. Keep away from heat, sparks, open flames, and strong oxidants. Store sealed in a cool, dry, dark area. Dispose of waste material in accordance with local environmental regulations.
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