- Assay (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
Applications
2-Amino-5-chloropyrimidine is a classic disubstituted pyrimidine heterocyclic intermediate with amino and chlorine functional groups on the pyrimidine ring. It possesses good chemical reactivity and can undergo diazotization, nucleophilic substitution, amination, coupling and condensation derivatization reactions. It is widely used as core building block for antiviral, antitumor, antibacterial and cardiovascular pharmaceutical intermediates, kinase inhibitor fragments and targeted small molecule drug synthesis. It is also extensively applied in medicinal chemistry structure-activity relationship study, custom fine chemical synthesis and new pesticide fungicide and herbicide development.
Safety Information
Irritating to skin, eyes and respiratory tract. Inhalation of dust may cause throat discomfort, dry cough and respiratory mucosal irritation; direct eye contact leads to stinging, redness and conjunctival congestion. Prolonged skin contact may cause dryness, itching and allergic inflammation. Avoid dust inhalation, skin adhesion and eye exposure. All operations must be performed in a fume hood with nitrile gloves, safety goggles and dust mask. Keep away from high temperature, open flame and strong oxidants. Store sealed in dry, dark and ventilated environment. Waste residues and packaging materials shall be disposed strictly in accordance with hazardous chemical regulations to prevent water and soil pollution.
Product
