- Assay (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
Applications
5-Bromo-2-chloropyrimidine is a dihalogenated substituted pyrimidine heterocyclic intermediate. Both 2-position chlorine and 5-position bromine have high chemical reactivity, capable of nucleophilic substitution, Suzuki coupling, Buchwald amination and multi-step derivatization reactions. It is widely used as core building block for antitumor, antiviral, antibacterial pharmaceutical intermediates, kinase inhibitor fragments and targeted small molecule drug synthesis. Also applied in medicinal chemistry structure-activity relationship research, custom fine chemical synthesis and new pesticide fungicide/herbicide molecular development.
Safety Information
Irritating to skin, eyes and respiratory tract. Inhalation of dust may cause throat discomfort, dry cough and respiratory mucosal irritation; direct eye contact leads to stinging, redness and conjunctival congestion. Prolonged skin contact may cause dryness and allergic irritation. Avoid dust inhalation, prolonged skin contact and eye exposure. All operations must be performed in a fume hood with nitrile gloves, safety goggles and dust mask. Keep away from high temperature, open flame and strong oxidants. Store sealed in dry, dark and ventilated environment. Waste residues and packaging materials shall be disposed strictly in accordance with hazardous chemical regulations to prevent water and soil pollution.
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