- Assay (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
Applications
5-Bromo-2-chloro-3-methylpyridine is a trisubstituted pyridine halogenated intermediate. Both 2-chloro and 5-bromo positions have high reactivity, suitable for nucleophilic substitution, Suzuki coupling, Sonogashira coupling and amination reactions. It is widely used as key building block for antitumor, anti-inflammatory, central nervous system drug intermediates, kinase inhibitor fragments and customized fine chemical synthesis; also applied in medicinal chemistry structure-activity relationship research and agrochemical intermediate development.
Safety Information
Irritating to skin, eyes and respiratory tract. Avoid dust inhalation, prolonged skin contact and eye exposure. Operate in fume hood with nitrile gloves, safety goggles and dust mask. Keep away from high temperature, open flame and strong oxidants. Store sealed in dry, dark and ventilated environment. Waste shall be disposed strictly in accordance with hazardous chemical regulations.
Product
