- Assay (HPLC): ≥98.0% (pharmaceutical grade can reach ≥99.0% to meet relevant chiral drug quality standards)
- Appearance: White to off-white crystalline powder
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
- Heavy Metal (as Pb): ≤10 ppm
- Specific Rotation: +35° to +40° (c=1.0, Chloroform)
Applications
CAS 90847-76-0 is a key chiral azetidinone intermediate, which contains multiple functional groups such as silyloxy, ester group and azetidinone ring, and has high chiral purity and chemical reactivity. It is mainly used in the synthesis of β-lactam antibiotics and chiral pharmaceutical intermediates, and is widely applied in pharmaceutical research, chemical synthesis and other fields.
- Pharmaceutical Research & Synthesis Field: It is an important intermediate for the synthesis of cephalosporin antibiotics and carbapenem antibiotics. The chiral structure and functional groups in its molecule can effectively regulate the antibacterial activity and pharmacokinetic properties of the target drug, and can be used to synthesize new β-lactam antibiotics with high efficiency, low toxicity and broad-spectrum antibacterial properties. It is also used in the synthesis of chiral azetidinone derivatives, which provides important support for the research and development of chiral drugs and the optimization of drug efficacy.
- Chemical Synthesis Field: As a chiral building block, it can undergo hydrolysis, deprotection, condensation, substitution and other chemical reactions. The tert-butyldimethylsilyl (TBDMS) group in the molecule can be removed under mild conditions to obtain hydroxyl-containing azetidinone intermediates, which can further participate in the synthesis of various pharmaceutical and fine chemical products. It is also used as a standard substance in chiral synthesis research and pharmaceutical quality control, ensuring the accuracy and reliability of synthesis and detection.
- Other Fields: It is used as a research reagent in the study of chiral synthesis methodology, the research of azetidinone ring reaction mechanism, and the development of new synthetic routes, providing a basis for the innovation and optimization of chemical synthesis technology.
Safety Information
- Hazard Category: Irritant (GHS hazard symbol: GHS07; hazard code: R36/37/38)
- Hazards: It is irritating to the skin, eyes and respiratory tract. Direct skin contact may cause redness, itching, dryness and allergic reactions; eye contact may lead to conjunctival hyperemia, burning sensation and corneal irritation; inhalation of dust may cause respiratory tract irritation, cough, chest tightness and other discomfort symptoms. Long-term or large-scale contact may have potential impacts on the respiratory system and skin, and there is no obvious acute toxicity, but accidental ingestion may cause gastrointestinal discomfort such as nausea and vomiting.
- Operation Precautions: All operations shall be carried out in a well-ventilated fume hood and under dark conditions (avoiding light); wear nitrile gloves, acid and alkali resistant protective clothing, safety goggles and dust mask to avoid direct contact, inhalation of dust and accidental ingestion. It is recommended to operate under the protection of inert gas to prevent degradation caused by contact with air and moisture. Do not eat, drink or smoke during operation; clean the face and hands thoroughly after operation. The operation area shall be equipped with emergency rescue equipment and first aid drugs.
- Storage & Transportation Requirements: It shall be stored in a sealed double aluminum vacuum packaging with desiccant inside, and the outer packaging shall be reinforced with HDPE barrel or cardboard barrel; the storage temperature shall be controlled at 2–8 ℃ (refrigeration), and it shall be protected from light, moisture and high temperature. The transportation shall adopt full cold chain (2–8 ℃), avoid violent vibration, sun exposure and moisture; it shall be transported in accordance with the regulations of general hazardous chemicals, and shall not be mixed with food, feed, strong oxidants, acids and alkalis.
- Waste Disposal: Waste residues and contaminated packaging shall be disposed of in strict accordance with the management regulations of hazardous chemicals, and shall not be directly discharged into water bodies, soil or sewers to avoid environmental pollution; the waste shall be collected and treated by professional hazardous waste disposal institutions in accordance with relevant regulations.
- First Aid Measures: In case of skin contact, immediately take off contaminated clothes, rinse thoroughly with plenty of soapy water and clean water for at least 15 minutes, and seek medical advice if there is discomfort; in case of eye contact, rinse with plenty of water for at least 15 minutes and seek medical advice in time; in case of accidental ingestion, do not induce vomiting, keep the patient in a supine position, and seek medical treatment immediately with the product label; in case of inhalation discomfort, move to a well-ventilated place and seek medical advice if symptoms persist.
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