1. Assay (HPLC): ≥98.0% (industrial grade); ≥99.0% (pharmaceutical grade); up to 99.5% (high-purity specification)
2. Appearance: Colorless to pale yellow transparent liquid
3. Loss on Drying (Moisture): ≤0.15% (in line with USP-NF and Chinese Pharmacopoeia standards)
4. Residue on Ignition: ≤0.1%
5. Single Impurity: ≤0.2% (pharmaceutical grade ≤0.3%)
6. Total Impurity: ≤1.0%
7. Heavy Metal (as Pb): ≤10 ppm
8. Refractive Index: 1.452–1.457 (20 ℃)

Applications

1. Pharmaceutical Synthesis Field: It is a key intermediate for the synthesis of non-steroidal anti-inflammatory drugs such as loxoprofen sodium, and is also used in the construction of the side chain of the antiviral drug remdesivir, the synthesis of celecoxib (COX-2 inhibitor) analogs, and the cyclization step of cyclopentane nucleoside analogs in anti-tumor prodrugs. It can realize the precise construction of chiral centers through asymmetric alkylation or enzyme-catalyzed dynamic kinetic resolution, and has irreplaceable value in the research and development of chiral drugs. It is also a core product of many pharmaceutical intermediate enterprises, with mature synthesis processes (mainly using Claisen condensation of cyclopentanone and dimethyl carbonate under the catalysis of potassium tert-butoxide, with a stable yield of 78–83%).
2. Fragrance and Flavor Industry: It is used as a modification component of fruit-flavored fragrance bases. Its cyclic structure endows the fragrance with better staying power and roundness, and is widely used in the formulation of daily chemical fragrances and food flavors, meeting the customization needs of fragrance and flavor customers for batch consistency of aroma precursors.
3. Fine Chemical Field: As a key building block, it can undergo alkylation, aldol condensation, Michael addition, cyclization and other reactions, and is used in the synthesis of complex organic compounds, heterocyclic compounds and aromatic derivatives, as well as the preparation of dyes, photoinitiators and other fine chemicals.
4. Material Science Field: Its bifunctional characteristics are used in the design of cross-linking monomers for degradable polyesters and precursors for metal-organic framework (MOF) ligands, providing support for the development of advanced functional materials.
5. Other Fields: It is used as a standard substance in analytical chemistry experiments and organic synthesis research, with clear structural confirmation signals (infrared absorption peaks at 1735 cm?1, 1710 cm?1 and 2950–2850 cm?1; characteristic 1H NMR signals in CDCl?), ensuring the accuracy of detection and synthesis processes; it is also used in the research of organic reaction mechanisms to optimize synthetic routes.

Safety Information

• Hazard Category: Irritant (GHS hazard symbol: GHS07; hazard code: R36/37/38; hazard statement: H227)
• Hazards: It is irritating to the skin, eyes and respiratory tract. Direct skin contact may cause redness, itching, dryness and mild allergic reactions; eye contact may lead to conjunctival hyperemia, burning sensation and corneal irritation; inhalation of vapor may cause respiratory tract irritation, cough, chest tightness and other discomfort symptoms. There is no obvious acute toxicity, but long-term or large-scale contact may have potential impacts on the respiratory system and skin; accidental ingestion may cause gastrointestinal discomfort such as nausea and vomiting.
• Operation Precautions: All operations shall be carried out in a well-ventilated fume hood; wear nitrile gloves, protective clothing, safety goggles and gas mask to avoid direct contact, inhalation of vapor and accidental ingestion. Do not eat, drink or smoke during operation; clean the face and hands thoroughly after operation. The operation area shall be equipped with emergency rescue equipment and first aid drugs; avoid contact with strong acids, strong bases and reducing agents to prevent side reactions.
• Storage & Transportation Requirements: It shall be stored in a sealed HDPE barrel or glass container, with desiccant inside; the storage temperature shall be controlled at 2–8 ℃ (refrigeration), protected from light, moisture, high temperature and open flame. Transportation shall avoid violent vibration, sun exposure and moisture, and shall be transported in accordance with the regulations of general hazardous chemicals (customs code: 29183000); it shall not be mixed with food, feed, strong oxidants, strong acids and strong bases. Common packaging specifications include 10g, 100g, 25kg and 200kg, which can meet the needs of laboratory and industrial production.
• Waste Disposal: Waste residues and contaminated packaging shall be disposed of in strict accordance with the management regulations of hazardous chemicals, and shall not be directly discharged into water bodies, soil or sewers to avoid environmental pollution; the waste shall be collected and treated by professional hazardous waste disposal institutions in accordance with relevant regulations.
• First Aid Measures: In case of skin contact, immediately take off contaminated clothes, rinse thoroughly with plenty of soapy water and clean water for at least 15 minutes, and seek medical advice if there is discomfort; in case of eye contact, rinse with plenty of water for at least 15 minutes and seek medical advice in time; in case of accidental ingestion, do not induce vomiting, keep the patient in a supine position, and seek medical treatment immediately with the product label; in case of inhalation discomfort, move to a well-ventilated place and seek medical advice if symptoms persist.