- Assay (HPLC): ≥98.0% (reagent grade and pharmaceutical intermediate common specification)
- Appearance: White crystalline powder
- Loss on Drying: ≤1.0% (mainly lost as crystal water)
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
- Heavy Metal (as Pb): ≤10 ppm
- Chloride Content (Cl?): 24.0–25.5% (consistent with the content of two hydrochloride groups in the molecular structure)
Applications
CAS 23279-12-1 is an important amino acid derivative, belonging to the category of tyrosine derivatives, with two functional groups (amino and hydroxyl) on the benzene ring and one amino group and one carboxyl group on the side chain, which has good chemical reactivity and biological activity. It is mainly used in pharmaceutical research, biochemical experiments, peptide synthesis and other fields, and is an important intermediate and research reagent.
- Pharmaceutical Research Field: It is used as a key intermediate in the synthesis of pharmaceutical products such as anti-tumor drugs, neuroprotective drugs and cardiovascular drugs. Its unique amino and hydroxyl substitution structure can regulate the biological activity and pharmacokinetic properties of target drugs, and is an important research object in the study of structure-activity relationship of pharmaceutical compounds. It can also be used in the synthesis of polypeptide drugs and bioactive molecules, providing support for the research and development of new drugs.
- Biochemical & Biomedical Field: It is used as a research reagent in biochemical experiments, such as the study of enzyme catalysis, protein synthesis and amino acid metabolism. It can be used as a substrate or standard substance in the detection of amino acid oxidase, tyrosine hydroxylase and other enzymes, ensuring the accuracy and reliability of experimental results. In addition, it is used in the research of cell culture and tissue engineering, providing essential nutrients for cell growth and differentiation.
- Peptide Synthesis Field: As a chiral amino acid building block, it can participate in solid-phase or liquid-phase peptide synthesis, and is used to prepare bioactive peptides with specific functions. Its chiral purity has an important impact on the activity and stability of the synthesized peptides, which is widely used in the synthesis of polypeptide drugs and peptide-based health products.
- Other Fields: It is used as a standard substance in analytical chemistry experiments, used for the calibration of detection instruments and the qualitative and quantitative analysis of amino acid derivatives; it is also used in the research of natural product chemistry, used to explore the synthesis and metabolism of tyrosine derivatives in organisms.
Safety Information
- Hazard Category: Irritant (GHS hazard symbol: GHS07; hazard code: R36/37/38)
- Hazards: It is irritating to the skin, eyes and respiratory tract. Direct skin contact may cause redness, itching, dryness and mild allergic reactions; eye contact may lead to conjunctival hyperemia, burning sensation and corneal irritation; inhalation of dust may cause respiratory tract irritation, cough, chest tightness and other discomfort symptoms. There is no obvious acute toxicity, but long-term or large-scale contact may have potential impacts on the respiratory system and skin; accidental ingestion may cause gastrointestinal discomfort such as nausea and vomiting.
- Operation Precautions: All operations shall be carried out in a well-ventilated fume hood and under dark conditions (avoiding light); wear nitrile gloves, protective clothing, safety goggles and dust mask to avoid direct contact, inhalation of dust and accidental ingestion. It is recommended to operate under the protection of inert gas to prevent degradation caused by contact with air and moisture. Do not eat, drink or smoke during operation; clean the face and hands thoroughly after operation. The operation area shall be equipped with emergency rescue equipment and first aid drugs.
- Storage & Transportation Requirements: It shall be stored in a sealed double aluminum vacuum packaging with desiccant inside, and the outer packaging shall be reinforced with HDPE barrel or cardboard barrel; the storage temperature shall be controlled at 2–8 ℃ (refrigeration), protected from light, moisture and high temperature. Transportation shall adopt full cold chain (2–8 ℃), avoid violent vibration, sun exposure and moisture; it shall be transported in accordance with the regulations of general hazardous chemicals, and shall not be mixed with food, feed, strong oxidants, strong bases and heavy metal compounds.
- Waste Disposal: Waste residues and contaminated packaging shall be disposed of in strict accordance with the management regulations of hazardous chemicals, and shall not be directly discharged into water bodies, soil or sewers to avoid environmental pollution; the waste shall be collected and treated by professional hazardous waste disposal institutions in accordance with relevant regulations.
- First Aid Measures: In case of skin contact, immediately take off contaminated clothes, rinse thoroughly with plenty of soapy water and clean water for at least 15 minutes, and seek medical advice if there is discomfort; in case of eye contact, rinse with plenty of water for at least 15 minutes and seek medical advice in time; in case of accidental ingestion, do not induce vomiting, keep the patient in a supine position, and seek medical treatment immediately with the product label; in case of inhalation discomfort, move to a well-ventilated place and seek medical advice if symptoms persist.
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