1. Assay (HPLC): ≥98.0% (pharmaceutical grade ≥99.0%, meeting USP/EP/BP standards)
2. Appearance: White to off-white crystalline powder
3. Loss on Drying: ≤0.5%
4. Residue on Ignition: ≤0.1%
5. Single Impurity: ≤0.2% (pharmaceutical grade ≤0.1%)
6. Total Impurity: ≤1.0%
7. Heavy Metal (as Pb): ≤10 ppm
8. Related Substances: Complies with pharmacopoeial standards (no obvious impurity peaks in HPLC detection)

Applications

1. Pharmaceutical Field: Clinically, it is mainly used for the treatment of hyperthyroidism (hyperthyroidism), including Graves' disease, toxic multinodular goiter, etc., which can inhibit the synthesis of thyroid hormones by blocking the oxidation of iodine ions and the coupling of iodotyrosine, thereby relieving symptoms such as palpitations, weight loss, and hyperhidrosis caused by hyperthyroidism. It is also used as an auxiliary drug for thyroid surgery and radioactive iodine treatment to control hyperthyroidism symptoms before treatment.
2. Pharmaceutical Research Field: As a classic anti-thyroid drug, it is used as a research tool in the study of thyroid hormone synthesis mechanism, the structure-activity relationship of thiol imidazole drugs, and the development of new anti-thyroid drugs. It is also used in the research of drug metabolism and pharmacokinetics to optimize drug dosage and reduce adverse reactions. Its synthesis process is mature, mainly prepared by amination, cyclization and condensation of chloroacetaldehyde diethyl acetal, methylamine and ethyl chloroformate.
3. Chemical Synthesis Field: It can be used as an intermediate for the synthesis of methimazole and other thiol imidazole derivatives, and can also be used as a standard substance in pharmaceutical quality control and analytical chemistry experiments, ensuring the accuracy and reliability of detection and synthesis processes.
4. Other Fields: It is used as a research reagent in biochemical experiments related to thyroid function, and is used to study the regulation mechanism of thyroid hormone synthesis and secretion; it is also used in the quality control of pharmaceutical preparations to ensure the safety and efficacy of drugs. In addition, it has a quick contact killing effect on rice planthoppers, black-tailed leafhoppers and rice bugs in agriculture.

Safety Information

• Hazard Category: Irritant (GHS hazard symbol: GHS07; hazard code: R22, R36, R43); hazard statements: H302, H317, H319
• Hazards: Toxic if ingested (H302). It is irritating to the skin, eyes and respiratory tract; direct skin contact may cause redness, itching, dryness and allergic reactions (H317); eye contact may lead to conjunctival hyperemia, burning sensation and corneal irritation (H319); inhalation of dust may cause respiratory tract irritation, cough, chest tightness and other discomfort symptoms. Long-term or excessive use may cause adverse reactions such as leukopenia, thrombocytopenia, and liver function damage; it may affect thyroid function in pregnant women and fetuses, and should be used with caution in special groups.
• Operation Precautions: All operations shall be carried out in a well-ventilated fume hood and under dark conditions (avoiding light); wear nitrile gloves, protective clothing, safety goggles and dust mask to avoid direct contact, inhalation of dust and accidental ingestion. Do not eat, drink or smoke during operation; clean the face and hands thoroughly after operation. The operation area shall be equipped with emergency rescue equipment and first aid drugs; follow the precautions for P261, P280a, P301+P312a, P305+P351+P338, P321, P501a.
• Storage & Transportation Requirements: It shall be stored in a sealed double aluminum vacuum packaging with desiccant inside, and the outer packaging shall be reinforced with HDPE barrel or cardboard barrel; the storage temperature shall be controlled at 2–8 ℃ (refrigeration), protected from light, moisture and high temperature. Transportation shall avoid violent vibration, sun exposure and moisture; it shall be transported in accordance with the regulations of hazardous chemicals (UN 3335), and shall not be mixed with food, feed, strong oxidants, strong acids and strong bases; the customs code is 2933.29.9000.
• Waste Disposal: Waste residues and contaminated packaging shall be disposed of in strict accordance with the management regulations of hazardous chemicals, and shall not be directly discharged into water bodies, soil or sewers to avoid environmental pollution; the waste shall be collected and treated by professional hazardous waste disposal institutions in accordance with relevant regulations.
• First Aid Measures: In case of skin contact, immediately take off contaminated clothes, rinse thoroughly with plenty of soapy water and clean water for at least 15 minutes, and seek medical advice if there is discomfort; in case of eye contact, rinse with plenty of water for at least 15 minutes and seek medical advice in time; in case of accidental ingestion, do not induce vomiting, keep the patient in a supine position, and seek medical treatment immediately with the product label; in case of inhalation discomfort, move to a well-ventilated place and seek medical advice if symptoms persist.
• Safety Instructions: S22 (Do not breathe dust); S36/37/39 (Wear suitable protective clothing, gloves and eye/face protection); WGK Germany: 3; TSCA: Yes.