- Assay (HPLC): ≥98.0% (common specification for reagent grade and pharmaceutical intermediates)
- Appearance: White to light yellow solid
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
- Heavy Metal (as Pb): ≤10 ppm
- Optical Rotation: 16.8°–17.8° (c=1g/100mL, CHCl?, 20℃, 589nm)
Applications
CAS 790667-49-1 is an important chiral piperidine derivative and organic synthetic intermediate, containing Boc-protecting group, carbonyl group and chiral methyl group in its molecular structure, with high chiral purity and good chemical reactivity. It is mainly used in pharmaceutical research, chemical synthesis, chiral drug development and other fields, and is an important building block for the synthesis of complex organic compounds and bioactive molecules.
- Pharmaceutical Research & Synthesis Field: It is a key chiral intermediate for the synthesis of pharmaceutical products such as anti-tumor drugs, antiviral drugs and central nervous system drugs. The chiral piperidine skeleton and functional groups in its molecule can effectively regulate the biological activity, pharmacokinetic properties and enantioselectivity of target drugs. It is widely used in the synthesis of piperidine-containing chiral drugs, and can be used to construct chiral centers in drug molecules, providing important support for the research and development of new drugs with high efficiency and low toxicity.
- Chemical Synthesis Field: As a chiral building block, it can undergo deprotection, reduction, alkylation, condensation and other chemical reactions. The Boc-protecting group in the molecule can be removed under mild acidic conditions to obtain free piperidine intermediates, which can further participate in the synthesis of various pharmaceutical and fine chemical products. It is also used as a standard substance in chiral synthesis research and pharmaceutical quality control, ensuring the accuracy and reliability of synthesis and detection processes.
- Chiral Drug Development Field: Its unique chiral structure makes it an important research object in the study of chiral synthesis methodology and structure-activity relationship of chiral drugs. It can be used to explore the influence of chiral configuration on drug efficacy, and provide a basis for the optimization of chiral drug synthesis routes and the improvement of drug purity.
- Other Fields: It is used as a research reagent in the study of organic reaction mechanisms, especially in the research of piperidine ring modification and chiral synthesis reactions, and provides support for the innovation and optimization of chemical synthesis technology; it is also used in the quality control of pharmaceutical intermediates to ensure the safety and stability of subsequent drug synthesis.
Safety Information
- Hazard Category: Irritant and toxic (GHS hazard symbol: GHS07; hazard statements: H302, H315, H319, H335)
- Hazards: Toxic if swallowed (H302). It is irritating to the skin, eyes and respiratory tract; direct skin contact may cause skin irritation (H315), such as redness, itching and dryness; eye contact may cause serious eye irritation (H319), such as conjunctival hyperemia, burning sensation and corneal irritation; inhalation of dust or vapor may cause respiratory tract irritation (H335), such as cough, chest tightness and other discomfort symptoms. Long-term or large-scale contact may have potential impacts on the respiratory system, skin and eyes; there is no complete toxicological data, and long-term exposure should be avoided; no sensitizing effects are currently known.
- Operation Precautions: All operations shall be carried out in a well-ventilated fume hood and under dark conditions (avoiding light); wear nitrile gloves, protective clothing, safety goggles and dust mask to avoid direct contact, inhalation of dust and accidental ingestion. Follow the prevention instructions P261, P264, P270, P271, P280. Do not eat, drink or smoke during operation; clean the face and hands thoroughly after operation. The operation area shall be equipped with emergency rescue equipment and first aid drugs; avoid contact with strong acids, strong bases, strong oxidants and reducing agents to prevent decomposition and side reactions.
- Storage & Transportation Requirements: It shall be stored in a sealed double aluminum vacuum packaging with desiccant inside, and the outer packaging shall be reinforced with HDPE barrel or cardboard barrel; the storage temperature shall be controlled at 2–8 ℃ (refrigeration), protected from light, moisture and high temperature. Follow the storage instructions P403+P233, P405. Transportation shall avoid violent vibration, sun exposure and moisture; it shall be transported in accordance with the regulations of general hazardous chemicals, and shall not be mixed with food, feed, strong oxidants, strong acids, strong bases and reducing agents; common packaging specifications include 10g, 100g, 25kg, which can meet the needs of laboratory and industrial production.
- Waste Disposal: Waste residues and contaminated packaging shall be disposed of in strict accordance with the management regulations of hazardous chemicals, follow the disposal instruction P501, and shall not be directly discharged into water bodies, soil or sewers to avoid environmental pollution; the waste shall be collected and treated by professional hazardous waste disposal institutions in accordance with relevant regulations.
- First Aid Measures: In case of skin contact, immediately take off contaminated clothes, rinse thoroughly with plenty of soapy water and clean water for at least 15 minutes, and seek medical advice if there is discomfort; in case of eye contact, rinse with plenty of water for at least 15 minutes and seek medical advice in time; in case of accidental ingestion, do not induce vomiting, keep the patient in a supine position, and seek medical treatment immediately with the product label; in case of inhalation discomfort, move to a well-ventilated place and seek medical advice if symptoms persist.
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