- Purity (HPLC): ≥98.0%
- Appearance: White crystalline powder, free of visible impurities
- Optical Purity (ee): ≥99.0%
- Moisture Content: ≤0.5%
- Residual Solvents: Meet USP/EP standards
- Heavy Metals: ≤10 ppm
- Loss on Drying: ≤1.0%
Applications
This compound is a critical chiral amino acid derivative and pharmaceutical intermediate, primarily used in the synthesis of protease inhibitors, especially HIV protease inhibitors and hepatitis C virus (HCV) protease inhibitors. Its unique structure, featuring a 2,4-difluorophenyl group and a Boc-protected chiral amino group, provides excellent metabolic stability and target binding affinity, making it a key building block for antiviral drug development. It is widely utilized in the preparation of novel antiviral agents, where the difluorophenyl moiety enhances lipophilicity and membrane permeability, while the chiral center ensures high selectivity for the enzyme active site. Additionally, it serves as an important intermediate in the synthesis of other biologically active compounds, including anti-inflammatory and anticancer agents. In academic research, it is used as a reference standard for chiral synthesis methodology development and as a tool compound for studying enzyme inhibition mechanisms. Its high optical purity and chemical stability make it indispensable for both industrial pharmaceutical production and laboratory-scale organic chemistry research.
Safety Information
This compound is classified as a low-toxicity irritant with specific handling precautions required. Direct contact with skin may cause mild irritation, redness, or dryness; prolonged or repeated exposure could lead to allergic dermatitis in sensitive individuals. Eye contact may result in conjunctival irritation, tearing, or discomfort, requiring immediate rinsing with plenty of water for at least 15 minutes. Inhalation of dust or fine particles may irritate the respiratory tract, causing cough, sore throat, or shortness of breath, especially in poorly ventilated areas. No severe acute toxicity has been reported, but accidental ingestion may cause mild gastrointestinal symptoms such as nausea, vomiting, or abdominal pain. All operations should be conducted in a well-ventilated fume hood or area; operators must wear appropriate personal protective equipment, including safety goggles, chemical-resistant gloves, and a dust mask. Store in a cool, dry, dark place at 2-8 °C, tightly sealed to prevent moisture and light exposure, and separated from oxidizing agents and strong bases. Avoid release into the environment. Dispose of waste material and contaminated packaging in accordance with local, state, and federal hazardous waste regulations to prevent environmental contamination.
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