(+)-Pinoresinol 4-O-β-D-glucopyranoside is a major active furofuran lignan extracted from Forsythia suspensa, widely used in pharmaceutical research, pharmacological experiments, content determination and natural product development. It exhibits significant biological activities including antioxidant, hypotensive effects and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibition, making it a valuable tool compound for researching related physiological and pathological mechanisms. In pharmaceutical research, it is extensively used in the development of hepatoprotective and antiviral drugs, as well as in the study of natural product-derived therapeutic agents. It also serves as a standard reference substance for the content determination and identification of Forsythia suspensa and its related Chinese medicinal preparations, ensuring the quality control of traditional Chinese medicine products. Additionally, it is applied in academic research on natural product chemistry, helping to explore the extraction, separation and structural modification of lignan compounds, and providing important support for the development of new natural drugs and health products.

This compound is a natural lignan derivative with low acute toxicity, but standard protective measures should be taken during handling and storage. It is non-irritating to the skin and respiratory tract under normal operation, but prolonged direct contact may cause slight dryness in sensitive individuals. Avoid inhalation of fine powder and direct contact with eyes; if eye contact occurs, rinse immediately with plenty of clean water for 15-20 minutes. Accidental ingestion of a small amount will not cause obvious toxic reactions, but excessive intake may lead to mild gastrointestinal discomfort. It should be stored in a tightly sealed container at 2–8 °C, away from high temperature, light and oxidants to prevent degradation and quality changes. During operation, wear disposable gloves and a dust mask, and work in a well-ventilated environment. Waste residues and contaminated packaging should be disposed of in accordance with general chemical waste regulations, and random discharge is prohibited to avoid environmental pollution.