- Purity (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder, no visible impurities
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Unknown Impurity: ≤0.2%
- Total Impurities: ≤1.0%
- Heavy Metals (as Pb): ≤10 ppm


Applications
CAS 364590-53-4 is a high-value, structurally complex benzo[b]thiophene derivative, serving as a core advanced pharmaceutical intermediate dedicated to the R&D and process optimization of novel small-molecule targeted drugs and immunomodulatory agents. It is a key precursor for the synthesis of highly selective STING (Stimulator of Interferon Genes) agonists, which are widely used in preclinical research for solid tumor immunotherapy, malignant melanoma treatment and metastatic cancer suppression, by regulating innate immune response and enhancing the body's tumor-killing activity. Meanwhile, it is a critical building block for the development of selective estrogen receptor modulators and anti-breast cancer drug candidates, with stable molecular structure and strong target binding affinity, effectively improving the metabolic stability and bioavailability of active pharmaceutical ingredients. Additionally, it is used in the synthesis of Aβ aggregation regulators and neuroprotective compounds for the research and development of anti-Alzheimer's disease and neurodegenerative disorder drugs. It is also widely used as a standard reference substance in in vitro pharmacological screening, target binding assays and drug metabolism research, providing reliable raw material support for innovative drug discovery, preclinical safety evaluation and synthetic process optimization in the field of medicinal chemistry.
Safety Information
This compound is a pharmaceutical-grade heterocyclic organic intermediate with low acute oral toxicity, but it has moderate to severe irritant effects on skin, eyes and respiratory mucosa, and special protective measures are required for all handling and storage operations. Inhalation of fine crystalline dust in a poorly ventilated environment will irritate the upper respiratory tract, causing persistent sore throat, dry cough, chest tightness and mild respiratory discomfort, and long-term inhalation exposure may cause chronic mucosal irritation. Direct skin contact can cause obvious local redness, itching, burning sensation and mild inflammatory reaction; prolonged repeated contact will damage the skin barrier, cause dryness, peeling and allergic contact dermatitis, especially for sensitive skin populations. Accidental eye contact can induce severe conjunctival congestion, persistent burning pain, tearing and foreign body sensation, which may cause corneal epithelial damage if not treated in time. Accidental ingestion may cause nausea, abdominal distension, mild gastrointestinal discomfort and digestive tract irritation. All operations must be carried out in a Class II fume hood with adequate ventilation; operators must wear chemical-resistant nitrile gloves, anti-splash safety goggles, dust respirators and anti-permeation lab coats to avoid direct contact with the body and inhalation of dust. The container must be kept tightly sealed, stored at low temperature and away from light, and strictly isolated from strong oxidants, strong acids and strong alkaline reagents to avoid structural degradation and safety risks. Waste materials, unused products and contaminated packaging must be disposed of in strict accordance with hazardous waste management regulations, and shall not be discharged into water, soil or domestic waste, so as to avoid environmental pollution and potential biological safety hazards.
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