- Purity (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder, no visible impurities
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
- Specific Rotation: [α]2?/D +15° ~ +19° (c=1, MeOH)
Applications
(S)-3-(4-(Benzyloxy)phenyl)-2-(2-chloroacetamido)propanoic acid is a high-value chiral amino acid derivative and a key pharmaceutical intermediate, widely used in the synthesis of peptide drugs, anti-inflammatory agents, and tyrosine kinase inhibitors. It contains multiple reactive functional groups, including a chiral center, chloroacetyl group, carboxyl group, and benzyloxy group, which enable it to undergo acylation, substitution, deprotection, and condensation reactions, making it a versatile building block for constructing complex pharmaceutical molecular skeletons. In peptide synthesis, it serves as a protected chiral amino acid precursor, used to prepare bioactive peptides and peptide-based drugs with high enantioselectivity and biological activity. In the field of anti-inflammatory drug research and development, it is an important intermediate for synthesizing selective cyclooxygenase inhibitors and anti-rheumatic drug candidates, effectively improving the drug’s efficacy and reducing side effects. Additionally, it is widely used in the synthesis of tyrosine kinase inhibitors for the treatment of tumors and cardiovascular diseases, as well as a standard reference substance in chiral chemistry research and pharmaceutical quality control. It also plays an important role in the development of new synthetic methodologies and the optimization of pharmaceutical synthesis processes, providing reliable raw material support for innovative drug discovery and industrial production.
Safety Information
This chiral amino acid derivative has moderate irritancy and potential health hazards, requiring strict protective measures during handling and storage. It is irritating to the skin; direct or prolonged contact can cause local redness, itching, dryness, and mild inflammatory reactions, especially in sensitive individuals. It poses a serious risk to the eyes; accidental contact can induce severe conjunctival congestion, burning pain, tearing, and even corneal damage if not treated promptly. Inhalation of its fine crystalline dust can irritate the respiratory mucosa, leading to symptoms such as sore throat, cough, chest tightness, and difficulty breathing, particularly in poorly ventilated working environments. Accidental ingestion may cause mild to moderate gastrointestinal discomfort, including nausea, vomiting, abdominal pain, and diarrhea, and long-term or excessive exposure may affect liver and kidney function. All operations must be carried out in a well-ventilated fume hood; operators must wear chemical-resistant nitrile gloves, safety goggles, a dust mask, and a lab coat to avoid direct contact with the skin, eyes, and respiratory tract. In case of skin contact, immediately rinse the affected area with plenty of clean water for at least 15 minutes; for eye contact, flush continuously with clean water for 15-20 minutes and seek medical attention promptly. The container must be kept tightly sealed to prevent moisture absorption and contamination, and stored at low temperature away from light, isolated from strong oxidants, strong acids, and strong bases. Waste residues, contaminated packaging, and cleaning wastewater must be disposed of in strict accordance with hazardous waste management regulations, and random discharge into water bodies or soil is strictly prohibited to avoid environmental pollution and potential ecological risks.
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