Enzalutamide is a potent, orally active non-steroidal anti-androgen and androgen receptor antagonist widely applied in clinical oncology and pharmaceutical research. It is primarily indicated for the treatment of metastatic castration-resistant prostate cancer and non-metastatic castration-resistant prostate cancer, effectively blocking androgen receptor signaling to inhibit tumor cell proliferation, migration and invasion. It suppresses three key biological processes including androgen binding, receptor nuclear translocation and DNA interaction, thereby cutting off the growth driving force of prostate cancer. Besides clinical medication, it serves as a critical reference standard for pharmaceutical impurity research, raw material quality detection and formulation development. It is also extensively adopted in preclinical mechanism exploration, tumor drug combination screening and biomedical experimental research, providing important support for the development of new anti-androgen analogs and targeted anticancer molecules.

Enzalutamide belongs to low acute toxicity compound but possesses strong biological activity and reproductive toxicity, requiring standardized operation and strict protection during handling. Direct skin contact may cause redness, dryness and allergic irritation, while eye exposure can lead to conjunctival congestion, stinging and tearing discomfort. Inhalation of fine crystalline powder will irritate respiratory mucosa, causing throat dryness, cough and mild chest tightness. It has teratogenic risk and may cause adverse effects on fetal development, so pregnant women must avoid any exposure. Personal protective equipment including chemical resistant gloves, safety goggles and dust mask should be worn during weighing and sampling. Keep sealed, dry, cool and away from light in storage, far from strong oxidants and high temperature environment. Waste residues and contaminated packaging must be treated strictly in accordance with hazardous waste rules, and arbitrary discharge into water and soil is prohibited to prevent potential ecological and biological hazards.