- Assay (HPLC): ≥98.0%
- Loss on Drying: ≤0.5%
- Specific Rotation: +205° ~ +215°
- Single Maximum Impurity: ≤0.5%
- Total Impurity: ≤1.0%
- Residue on Ignition: ≤0.1%
- Heavy Metals: ≤10 ppm
Applications
Tenofovir is a nucleotide reverse transcriptase inhibitor with potent antiviral activity. It is a key pharmaceutical intermediate for the production of anti-HIV and anti-hepatitis B virus (HBV) drugs. Its mechanism involves being converted into an active diphosphate metabolite in cells, which competes with natural nucleotides to bind viral reverse transcriptase, thereby blocking viral DNA synthesis and replication. It is widely used in the synthesis of antiviral drugs such as Tenofovir Disoproxil and Tenofovir Alafenamide, and is an essential raw material in the treatment of HIV-1 infection and chronic hepatitis B.
Safety Information
This product has low acute toxicity but may cause mild irritation to the skin, eyes, and respiratory tract.
- Inhalation: Dust may cause sore throat, dry cough, and slight respiratory discomfort.
- Skin Contact: May cause local redness, itching, and mild inflammation.
- Eye Contact: Causes stinging pain and conjunctival congestion; rinse immediately with plenty of water for ≥15 minutes.
- Ingestion: May cause nausea, abdominal distension, and mild gastrointestinal discomfort.
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