- Appearance: White crystalline powder
- Purity (HPLC): ≥97.0%
- Melting Point: 58–60 °C
- Moisture (Karl Fischer): ≤0.5%
- Residue on Ignition: ≤0.1%
- Heavy Metals (Pb): ≤10 ppm
- Single Impurity (HPLC): ≤0.5%
Applications
CAS 88553-89-3 is a fluorinated aromatic intermediate widely used in pharmaceutical, agrochemical, and organic synthesis. It features a trifluoroethoxy group linked to a phenol ring, endowing it with high chemical stability and lipophilicity. In agrochemicals, it serves as a key building block for synthesizing selective herbicides, fungicides, and insecticides, where the fluorinated moiety enhances bioactivity, metabolic stability, and environmental safety. In pharmaceuticals, it is used to prepare anti-inflammatory, analgesic, and anti-cancer agents, as well as antiparasitic drugs (e.g., for flea/tick control in animals), leveraging its ability to improve target binding and pharmacokinetic properties. It is also employed in organic synthesis for nucleophilic substitution, coupling reactions (Suzuki/Mizoroki–Heck), and condensation, enabling the construction of complex fluorinated molecules. Additionally, it acts as a precursor for liquid crystal materials and fluorescent dyes, where its aromatic conjugation and halogen substituents tune optical and electrical properties.
Safety Information
Classified as GHS07 (H302, H315, H319, H332, H335); harmful, irritant.
- Inhalation: Dust/vapor irritates respiratory tract (cough, throat irritation); use local exhaust and dust mask.
- Skin Contact: Causes mild irritation (redness, itching); wear nitrile gloves, wash skin with soap and water.
- Eye Contact: Causes severe irritation (stinging, tearing, redness); wear safety goggles, rinse eyes with water for ≥15 minutes and seek medical help.
- Ingestion: Harmful if swallowed (nausea, vomiting, abdominal pain); do not induce vomiting, drink water and seek medical aid.
- Chemical Hazards: Stable under normal conditions; avoid strong oxidants, strong bases, and high temperatures (>280 °C), which may cause decomposition and release toxic fumes (HCl, HF, CO).
- Storage: Keep in cool, dry, well-ventilated area in tightly sealed containers; separate from incompatible substances.
- Disposal: Dispose of waste per local hazardous waste regulations; avoid release to environment.
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