- Appearance: Uniform dark solid powder
- HPLC Purity: ≥98.0% (typical ≥98.5%)
- Moisture: ≤0.5%
- Residue on Ignition: ≤0.1%
- Heavy Metals: ≤10 ppm
- Storage Condition: -20 °C, sealed, away from light
Applications
Verteporfin is a benzoporphyrin derivative and a clinically used photosensitizer for photodynamic therapy (PDT).
- Ophthalmology: First-line PDT agent for age-related macular degeneration (AMD); selectively damages abnormal ocular neovascularization under 689 nm laser.
- Oncology: Investigational YAP-TEAD inhibitor; disrupts YAP/TEAD interaction, induces tumor cell apoptosis, and inhibits autophagy (blocks autophagosome formation).
- Research Tool: Widely used in cancer biology to study Hippo pathway and autophagy mechanisms.
Safety Information
GHS Classification: Not fully classified; handle as a bioactive compound with light toxicity.
- Phototoxicity: Strong photosensitizer; avoid light exposure after handling—may cause skin/eye photodamage.
- Skin Contact: May cause irritation or allergic reaction; wear nitrile gloves.
- Eye Contact: Risk of severe irritation; wear goggles.
- Inhalation: Dust may irritate respiratory tract; use fume hood.
- Storage: Keep at -20 °C, protected from light; separate from oxidants.
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