- Appearance: Off-white solid powder
- Purity (HPLC): ≥98.0%
- Melting Point: Not available
- Moisture: ≤0.5%
- Residue on Ignition: ≤0.1%
- Heavy Metals: ≤10 ppm
- Related Substances: ≤1.0%
Applications
- Biochemical Research: Potent ATP-competitive inhibitor of Src, Abl, and Kit kinases.
- Anticancer Research: Exhibits antiproliferative activity against CML (chronic myeloid leukemia) cell lines and Bcr-Abl-transformed cells (IC?? = 14 nM).
- Mechanism Study: Blocks Bcr-Abl tyrosine phosphorylation, induces G0/G1 cell cycle arrest, and promotes apoptosis in Kit-mutated tumor cells.
- Drug Development: Tool compound for researching kinase signaling pathways and developing targeted anticancer drugs.
Safety Information
GHS Hazard: H315 (skin irritation), H319 (eye irritation), H335 (respiratory irritation).
- Handling: Wear nitrile gloves, safety goggles, and dust mask; operate in a fume hood.
- Storage: Store at -20°C, sealed, under inert gas (nitrogen/argon), away from light and moisture.
- Disposal: Dispose of as hazardous waste in accordance with local regulations.
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