- Appearance: Colorless to almost colorless clear liquid
- Purity (Argentometric Titration): 55.0–65.0 wt% (in hexanes)
- Specific Rotation [α]??/D: ?40.0° to ?50.0°
- Moisture: ≤0.1%
- Free Chloride: ≤0.5%
- Residue on Ignition: ≤0.1%
Application
88021-73-2 is a highly enantioselective chiral reducing agent used in asymmetric synthesis and pharmaceutical intermediate manufacturing. It is a proprietary analog of (?)-DIP?Chloride, designed for improved stability and stereoselectivity in industrial processes. It reduces prochiral ketones (aromatic, α,β?unsaturated, cyclic) to chiral secondary alcohols with ee >95%, a critical step in producing single?enantiomer drugs (antivirals, analgesics, antihypertensives). It is also used for chiral center construction in complex natural products and fine chemicals. Its high solubility in nonpolar solvents and tolerance for low?temperature reactions (?78 °C) ensure high yields and stereopurity. In academic research, it serves as a tool to study chiral induction mechanisms. Due to its proprietary nature, it is supplied only to qualified industrial and research clients under controlled conditions.
Safety Information
GHS classification: Flam. Liq. 2, Skin Corr. 1B, Eye Dam. 1, Asp. Tox. 1, STOT SE 3, Repr. 2, Aquatic Chronic 2. Signal word: Danger.
- Hazards: H225 (Highly flammable liquid/vapor), H314 (Severe skin burns/eye damage), H304 (Fatal if swallowed/enters airways), H336 (Drowsiness/dizziness), H361f (Suspected fertility damage), H411 (Toxic to aquatic life, long?lasting).
- Precautions: P210 (Keep away from heat), P280 (Protective gloves/clothing/eye/face protection), P260 (Do not breathe vapors), P301+P310 (If swallowed, call doctor immediately), P303+P361+P353 (Skin contact: remove clothing, rinse water), P305+P351+P338 (Eye contact: rinse 15 min, seek medical help).
- First Aid: Inhalation – fresh air; Skin – rinse 15 min, remove contaminated clothing; Eyes – rinse 15 min, urgent medical care; Ingestion – do not induce vomiting, call poison control.
- Storage/Disposal: Sealed under N? at 2–8 °C; dispose as hazardous waste per local regulations.
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