- Appearance: Yellowish crystalline powder
- Purity (HPLC): ≥98.0%
- Melting Point: 118–122 °C
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Heavy Metals (Pb): ≤10 ppm
- Related Substances: ≤1.0%
Uses
5,6-Dimethoxy-1-indanone is a critical pharmaceutical and organic intermediate, most notably used in the synthesis of Donepezil, a first-line drug for Alzheimer’s disease that improves cognitive function by inhibiting acetylcholinesterase. It serves as a key building block in the pharmaceutical industry for manufacturing other central nervous system (CNS) agents, particularly those targeting neurodegenerative disorders, due to its unique indanone structure that aids in binding to neural receptors. In organic synthesis, it is employed to prepare various substituted indanone derivatives, which are used as intermediates for dyes, pigments, and agrochemicals. Additionally, it acts as a research chemical in neuroscience studies, helping to explore mechanisms of neuronal cell death and develop neuroprotective agents. Its high purity and stable chemical properties make it suitable for GMP-compliant pharmaceutical production and laboratory-scale synthesis of complex molecules.
Safety Information
5,6-Dimethoxy-1-indanone is classified as GHS07 (Warning) with mild acute hazards. H302: Harmful if swallowed; H315: Causes skin irritation; H319: Causes serious eye irritation; H332: Harmful if inhaled; H335: May cause respiratory irritation. Acute toxicity data shows oral LD?? (rat) >2000 mg/kg and dermal LD?? (rabbit) >5000 mg/kg, indicating low acute toxicity. Inhalation of dust may trigger mild respiratory discomfort, while skin contact may cause redness or itching, and eye contact may lead to temporary irritation. It is combustible but not highly flammable; avoid contact with strong oxidants, which may cause reactions. For handling, use in well-ventilated areas or fume hoods, wear nitrile gloves, safety goggles, and dust masks. In case of skin contact, rinse with plenty of water; for eye contact, flush with water for 15 minutes. Store in cool, dry, dark areas away from heat sources. Dispose as non-hazardous waste per local regulations.
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