- Appearance: Colorless to pale yellow clear liquid
- Purity (GC): ≥99.0%
- Moisture: ≤0.1%
- Boiling Range: 172–174 °C
- Refractive Index: 1.524–1.526 (20 °C)
- Density: 1.408–1.410 g/mL (25 °C)
Application
2,4-Dichloro-1-fluorobenzene is a critical fluorinated aromatic intermediate widely used in pharmaceutical, agrochemical, and material synthesis. In the pharmaceutical industry, it serves as a key starting material for manufacturing fluoroquinolone antibiotics (e.g., ciprofloxacin), one of the most important antibacterial agents. It is also used in the synthesis of antiviral, anti-inflammatory, and antitumor drug intermediates. In agrochemicals, it is a vital intermediate for producing herbicides, insecticides, and fungicides, especially for fluorine-containing pesticides with high efficiency and low toxicity. Additionally, it is applied in the synthesis of functional materials such as liquid crystals, dyes, and fluorinated polymers. Its unique electron-withdrawing effect from fluorine and chlorine atoms enables diverse aromatic substitution reactions, making it a versatile building block for introducing fluorine and chlorine into organic molecules in fine chemical synthesis.
Safety Information
GHS02, GHS07 (Warning): Flammable liquid; harmful if swallowed; skin irritant.
- Routes of Entry: Inhalation, ingestion, skin/eye contact
- Acute Toxicity: Oral LD50 (rat) >500 mg/kg (Category 4); low dermal toxicity
- Skin Contact: Causes irritation, redness, itching; may cause allergic reactions with prolonged exposure
- Eye Contact: Irritating; may cause temporary corneal irritation; rinse with plenty of water for 15 minutes and seek medical attention
- Inhalation: Vapor may irritate respiratory tract, causing cough or discomfort; use in well-ventilated areas with respiratory protection
- Ingestion: Harmful; may cause nausea, vomiting, abdominal pain; do not induce vomiting, seek medical attention immediately
- Precautions: Keep away from heat, sparks, open flames; use explosion-proof equipment; wear gloves, goggles, and protective clothing
- Storage: Store in a cool, dry, well-ventilated warehouse; separate from strong oxidants
- Transport: UN 1993, Class 3 Flammable Liquid, Packing Group III
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