- Appearance: White to light-yellow powder
- Purity (HPLC): ≥98.0%
- Enantiomeric Excess (ee): ≥99%
- Melting Point: Not available
- Water Content: ≤0.5%
- Residue on Ignition: ≤0.1%
- Related Substances: ≤0.5%
Application
This compound is a chiral phosphoric acid catalyst derived from BINOL, bearing electron-withdrawing trifluoromethyl groups at the 3,3′-positions. It is widely used in asymmetric organic synthesis, including Friedel–Crafts reactions, Diels–Alder cycloadditions, and imine reductions. The strong acidity and chiral cavity enable high enantioselectivity (often >90% ee) in C–C and C–N bond formations. It serves as a key catalyst for synthesizing chiral pharmaceuticals, agrochemicals, and natural products. In academic research, it is a benchmark catalyst for developing new asymmetric methodologies. Due to its stability and high activity, it is favored in both laboratory and industrial pilot-scale synthesis.
Safety Information
GHS classification: Not fully classified; treat as irritant.
- Inhalation: Dust may irritate respiratory tract → cough, sore throat.
- Skin Contact: May cause irritation, redness, itching; risk of allergic reaction in sensitive individuals.
- Eye Contact: May cause severe irritation, tearing, conjunctival redness.
- Ingestion: May cause nausea, vomiting, diarrhea; no acute toxicity data available.
- Handle in a fume hood; wear nitrile gloves, safety goggles, and dust respirator.
- Avoid contact with strong bases, amines, and oxidants; may react violently.
- Skin: Wash with soap and water for 15 min.
- Eyes: Flush with water for ≥15 min; seek medical care.
- Ingestion: Rinse mouth; do not induce vomiting; get medical help.
- Store sealed under inert gas (N?/Ar) at room temperature, away from moisture and light.
- Dispose of waste per local hazardous waste regulations; avoid environmental release.
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