- Appearance: Off-white to pale beige powder
- Purity (HPLC): ≥99.0%
- Calcium Content: 7.5–8.2%
- Water Content: 10–17%
- Specific Rotation: ?10.0° to ?15.0°
- pH (5% solution): 7.5–8.5
- Residue on Ignition: ≤0.1%
- Heavy Metals (Pb): ≤10 ppm
Application
Calcium levofolinate is the pharmacologically active (S)-isomer of leucovorin, a critical folate antagonist antidote and chemotherapy adjuvant. It counteracts toxicity of methotrexate and other dihydrofolate reductase inhibitors by providing reduced folate cofactors for one-carbon transfer reactions. Clinically, it is used for “leucovorin rescue” after high-dose methotrexate in osteosarcoma and to treat accidental folate antagonist overdose. It also enhances efficacy of 5-fluorouracil in colorectal cancer by stabilizing ternary complexes with thymidylate synthase. As a pharmaceutical intermediate, it serves as a key raw material for injectable formulations and analytical reference standards in oncology drug development.
Safety Information
GHS Classification:
Not classified as hazardous (pharmaceutical grade)
Hazards: May cause mild eye/respiratory irritation; hygroscopic, avoid moisture
- Use in well-ventilated area; wear nitrile gloves, safety goggles, dust mask
- Avoid inhalation, skin/eye contact; prevent exposure to light and moisture
- Skin: Rinse with soap and water for 15 minutes; remove contaminated clothing
- Eyes: Flush with water for 15 minutes; seek medical attention if irritation persists
- Ingestion: Rinse mouth; do not induce vomiting; consult a physician
- Store sealed, ?20 °C, dark, dry; separate from oxidants, strong acids
- Dispose as pharmaceutical hazardous waste per local regulations; avoid environmental release
Transport: Not regulated as dangerous goods; protect from light/moisture.
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