4-(hidroximetil)-5-metil-1,3-dioxol-2-ona
2026-04-14
产品详情
- Cas:91526-18-0
- 产品名称4-(hidroximetil)-5-metil-1,3-dioxol-2-ona
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- 简介
- Assay(GC): ≥95.0%
- Moisture: ≤0.20%
- Residual solvent(MeCN): ≤500ppm
- Heavy metal(Pb): ≤10ppm
- Fe: ≤5ppm
- Related single impurity: ≤0.5%
- Total impurities: ≤2.0%


Applications
This dioxolone derivative is core pharmaceutical intermediate mainly applied for Olmesartan Medoxomil and Azilsartan API production, used to synthesize medoxomil ester side chain of sartan antihypertensive drugs. Its reactive hydroxyl and cyclic carbonate group enable esterification coupling with parent drug molecule to form prodrug medoxomil moiety for improving oral bioavailability. Besides bulk pharma synthesis, it serves as building block for custom fine chemical synthesis and new heterocyclic compound research in lab scale. Standard packing: 25L/200L sealed PE drum under nitrogen protection; widely supplied to pharmaceutical intermediate factories and custom synthesis labs globally. High-purity grade ≥96% for pharmaceutical grade, regular 93%~95% for pilot synthesis.
Safety Information
GHS:H315,H319,H335;Signal Word:Warning
Irritating to skin, eyes and respiratory tract. Skin contact triggers redness and itchiness, flush contaminated skin with running clean water over 15 minutes. Liquid splashed into eyes causes lacrimation and conjunctiva irritation, continuous eye rinse ≥15min and seek medical aid if discomfort persists. Inhalation of volatile vapor induces cough and throat pain; all operations need well-ventilated workshop with nitrile gloves, safety goggles and organic vapor respirator. Avoid mixing with strong acid and strong alkali to prevent hydrolysis and exothermic reaction. Store sealed under nitrogen at ≤-20℃ away from oxidants and food chemicals; waste liquid handled following local hazardous waste disposal regulation.
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