Product
Product
Product Name: 17-(3-pyridyl)-5,16-androstadien-3beta-acetate (Abiraterone Acetate)
CAS No.: 154229-18-2
Molecular Formula: C??H??NO?
Molecular Weight: 391.55
Appearance: White to off-white crystalline powder
Purity (HPLC): ≥99.5% (Result: 99.82%)
Maximum Single Impurity: ≤0.10% (Result: 0.06%)
Total Impurities: ≤0.50% (Result: 0.18%)
Water Content: ≤0.50% (Result: 0.21%)
Residue on Ignition: ≤0.10% (Result: 0.05%)
Heavy Metals: ≤10ppm (Compliant)
Melting Point: 127–130℃ (Result: 128.1–129.5℃)
Solubility: Practically insoluble in water, soluble in DMSO and chloroform, slightly soluble in methanol
Conclusion: Complies with USP/EP pharmaceutical grade standards
This product is a high-purity steroidal anti-tumor API and the core raw material of clinical first-line targeted drug Abiraterone Acetate. After in-vivo hydrolysis, it produces active metabolites that selectively and potently inhibit CYP17A1 enzyme. This enzyme is essential for androgen synthesis in adrenal glands, testes and prostate tumor tissues. Inhibition can completely block endogenous androgen production, fundamentally cutting off the hormone source for prostate cancer cell proliferation and suppressing tumor growth and metastasis. It is mainly used for pharmaceutical formulation of metastatic castration-resistant prostate cancer and high-risk metastatic hormone-sensitive prostate cancer. Combined with prednisone, it effectively prolongs survival and relieves clinical symptoms of advanced patients. Additionally, it is widely applied in pharmaceutical scientific research, including anti-tumor pharmacological tests, preparation development and target mechanism studies, serving as a key material for oncology drug research and industrial production.
As a bioactive steroidal pharmaceutical raw material, this substance has specific biological toxicity and requires standardized pharmaceutical chemical operation and storage. It is classified as GHS08 health hazard with H360 reproductive toxicity and H372 target organ toxicity, causing liver and kidney damage after long-term exposure. Direct oral ingestion, dust inhalation and extensive skin contact are strictly prohibited. Operators must wear nitrile gloves, goggles and dust masks in fully ventilated workshops to prevent dust dispersion. The product is chemically stable at room temperature, non-flammable and non-explosive, and not classified as dangerous goods for transportation. It shall be stored in sealed, light-proof, dry and low-temperature conditions, away from heat sources, food and daily supplies. Improper exposure may increase liver and kidney metabolic burden. Skin contact requires immediate flushing with plenty of clean water, and eye exposure needs prompt medical treatment. Pregnant and preparing-pregnancy personnel are forbidden to contact. Waste materials must be disposed of as hazardous waste to avoid health risks.
