Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Thymosin alpha 1 (Tα1), with CAS No. 62304-98-7, is a naturally occurring acetylated polypeptide composed of 28 amino acids, also known as Thymalfasin or Zadaxin. It is originally isolated from mammalian thymus tissue, and its synthetic form has the same sequence as the endogenous thymosin alpha 1 in the human body, with no immunogenicity and high safety. This product appears as a sterile, white lyophilized (freeze-dried) crystalline powder, with uniform particle size, no visible impurities, and no obvious odor. It possesses significant immunomodulatory, anti-inflammatory, and antiviral properties, and can enhance the immune response of the body by promoting the maturation of T lymphocytes and increasing the secretion of lymphokines. Widely applied in pharmaceutical R&D, biochemical experiments, and clinical research fields, it serves as a core raw material for immunomodulatory drugs, a research tool for immune function-related experiments, and an adjuvant for vaccine research and development, providing reliable support for medical research, drug production, and clinical immunotherapy.
1. Physical Properties
Thymosin alpha 1 is a sterile white lyophilized crystalline powder with uniform particle size, no visible impurities, and no obvious odor. It has a molecular weight of 3108.32 Da, a predicted density of 1.36 g/cm3 at 20°C, and a predicted boiling point of 2899.7±65.0 °C. It is well soluble in water and PBS buffer (pH 7.0-7.4), slightly soluble in ethanol, and insoluble in non-polar organic solvents such as chloroform and ether; its solubility in water can reach more than 40 mg/mL, and it remains clear and transparent even at high concentrations without aggregation or precipitation. The lyophilized powder has good stability at room temperature for a short time but is prone to moisture absorption, so it needs to be stored in a sealed and dry environment.
2. Chemical Properties
Chemically, Thymosin alpha 1 is an acetylated linear polypeptide composed of 28 amino acids, with an N-terminal acetylation modification that effectively blocks aminopeptidase degradation sites and enhances its enzyme hydrolysis resistance. Its peptide chain contains 12 acidic amino acids and 5 basic amino acids, showing strong acidity and carrying a strong negative charge in the physiological environment; it also has an amphiphilic structure with hydrophilic and hydrophobic ends, which can freely penetrate cell membranes and nuclear membranes to bind to target receptors. It has excellent chemical stability, with no easily oxidized amino acid residues in the sequence, and no oxidation inactivation risk; it is stable under acidic and low-temperature conditions, but extreme acid-base environments will cause peptide bond breakage and conformational damage, affecting its biological activity.
3. Storage & Safety Properties
Storage: It should be stored in a sealed, dry, and light-proof environment at -20°C, avoiding repeated freeze-thaw cycles, high temperature, moisture, and direct sunlight. The aqueous solution after reconstitution can be stored at 4°C for 1-4 weeks, and it is recommended to add carrier proteins (such as 0.1% HSA or BSA) for long-term storage to improve stability. Keep the packaging intact to prevent moisture absorption, contamination, and loss of biological activity; avoid mixing with strong oxidants and corrosive substances.
Safety: Thymosin alpha 1 is a non-toxic endogenous polypeptide, with an adverse reaction rate of less than 1%, and the main adverse reactions are mild local reactions at the injection site. It has no immunogenicity, will not trigger the body's immune response, and has no obvious cytotoxicity even at high concentrations. When handling, wear appropriate protective equipment (gloves, goggles, sterile operating clothes), and operate in a sterile environment to avoid contamination. In case of accidental contact with skin or eyes, rinse thoroughly with plenty of sterile water immediately. This product is for pharmaceutical R&D, scientific research, and clinical research use only, not for direct human use without formulation.
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