Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
2,4,6-Trichloropyrimidine, with CAS No. 3764-01-0, is a high-purity heterocyclic organic compound, also known as TPI or 2,4,6-Trichlopyrimidine. It is mainly synthesized by the chlorination reaction of barbituric acid with phosphorus oxychloride (POCl?) in the presence of a catalyst (such as N,N-dimethylformamide or composite amines), with a yield of 80-94% and high purity after purification. This product appears as a clear colorless to pale yellow liquid or low-melting crystalline solid (melting at 23-25°C), with a slight pungent odor, uniform texture and no visible impurities. It has unique chemical reactivity due to its π-deficient pyrimidine core and three activatable chlorine substituents, making it a pivotal building block in organic synthesis. It is widely used in pharmaceutical R&D, pesticide synthesis, dye production and material science fields, serving as a key intermediate for antiviral, antitumor and antimicrobial drugs, as well as pesticides and functional materials, providing reliable support for industrial production, scientific research and related application fields.
1. Physical Properties
2,4,6-Trichloropyrimidine is a colorless to pale yellow liquid or low-melting crystalline solid, with a slight pungent odor, uniform texture and no visible impurities. It has a molecular weight of 183.42 Da, a melting point of 23-25°C (lit.), and a density of 1.595 g/mL at 20°C (lit.). Its boiling point is 210-215°C (lit.), the flash point is 113°C (or >230°F), and the refractive index is n20/D 1.57 (lit.). It is insoluble in water but soluble in common organic solvents such as chloroform, ethyl acetate and benzene; it is a low-melting compound, which may present a semi-solid and semi-liquid state at higher ambient temperatures. It has no obvious hygroscopicity, but is sensitive to light and heat, so it needs to be stored in a low-temperature, sealed and light-proof environment to maintain its stability.
2. Chemical Properties
Chemically, 2,4,6-Trichloropyrimidine is a heterocyclic compound containing a pyrimidine ring with three chlorine atoms substituted at the 2, 4, and 6 positions. Its molecular structure has a π-deficient pyrimidine core, and the electron-withdrawing effect of the nitrogen atoms in the ring makes the carbon atoms at the 2, 4, and 6 positions highly susceptible to nucleophilic attack, giving it high chemical reactivity. The three chlorine atoms in the molecule have differential reactivity, with the order of nucleophilic substitution reactivity being C4/C6 > C2, which allows sequential and regioselective substitution reactions. It is relatively stable under normal temperature and pressure, but can undergo hydrolysis, condensation and other reactions under extreme acid-base conditions; the chlorine atoms in the molecule can be replaced by amino, hydroxyl and other groups, which is an important reaction basis for its application as an intermediate. It is incompatible with strong oxidants and strong bases, and may decompose under high temperature conditions.
3. Storage & Safety Properties
Storage: It should be stored in an inert atmosphere, sealed, dry and light-proof environment at 2-8°C, avoiding high temperature, direct sunlight, moisture and strong oxidants. The packaging should be kept intact to prevent leakage, contamination and performance degradation; it should not be mixed with toxic, harmful, corrosive substances and strong bases. When taking, minimize the contact time with air and oxygen, and seal the packaging immediately after use to avoid oxidation. It should be stored separately from other reactive chemicals, and no special requirements are needed for storerooms and receptacles except for low-temperature conditions.
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