Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
2-(Trimethylsilyl)ethanol, with CAS No. 2916-68-9, is a high-purity organosilicon compound, also known as (2-Hydroxyethyl)trimethylsilane or TMS ethanol. Its linear formula is (CH?)?SiCH?CH?OH, which consists of a trimethylsilyl group ((CH?)?Si-) attached to a 2-hydroxyethyl chain, combining the characteristics of organosilicon compounds and alcohols. This product is mainly synthesized through the addition reaction of trimethylchlorosilane with ethylene oxide, with high purity after distillation purification. It appears as a clear, colorless liquid at room temperature, with no visible impurities and a slight characteristic odor. It has unique chemical properties due to the presence of the trimethylsilyl group, which enables it to serve as an excellent protecting group for carboxylic acids, phosphates, hydroxyls, and amines in organic synthesis, and can be selectively deprotected under mild conditions. It is widely used in organic synthesis, pharmaceutical R&D, analytical chemistry, and material science fields, serving as a key intermediate for drug synthesis, a derivatizing agent in gas chromatography (to improve the detection and analysis of polar compounds), and a raw material for functional materials, providing reliable support for industrial production, scientific research and related application fields[5].
1. Physical Properties
2-(Trimethylsilyl)ethanol is a clear, colorless liquid at room temperature, with no visible impurities and a slight characteristic odor. It has a molecular weight of 118.25 Da, a melting point of 0°C (lit.), and a density of 0.825 g/mL at 25°C (lit.). Its boiling point is 71-73°C at 35 mmHg or 145°C at 760 mmHg (lit.), the flash point is 50°C (122°F), and the refractive index is n20/D 1.423-1.427 (lit.). It is soluble in common organic solvents such as chloroform and ethyl acetate, and slightly soluble in water; it has no obvious hygroscopicity, but is flammable and sensitive to heat and ignition sources, so it needs to be stored in a low-temperature, sealed and light-proof environment to maintain its stability[7].
2. Chemical Properties
Chemically, 2-(Trimethylsilyl)ethanol is an organosilicon compound containing both a trimethylsilyl group ((CH?)?Si-) and a hydroxyl group (-OH) in its molecular structure, combining the chemical characteristics of organosilicon and alcohol. The trimethylsilyl group in the molecule is electron-donating and has good steric hindrance, making it an excellent protecting group for various functional groups (carboxylic acids, phosphates, hydroxyls, amines) in organic synthesis, and it can be selectively deprotected under mild conditions without affecting other functional groups. The hydroxyl group in the molecule can undergo common alcohol reactions such as esterification, etherification and oxidation. It is relatively stable under normal temperature and pressure, and will not decompose when used and stored in accordance with regulations; it is incompatible with strong oxidants, and may undergo side reactions under extreme acid-base conditions. Its molecular structure is stable, and it is easy to purify, which is conducive to its application in organic synthesis and analytical chemistry fields[5].
3. Storage & Safety Properties
Storage: It should be stored in a sealed, dry and light-proof environment at 0-6°C, avoiding high temperature, direct sunlight, moisture and ignition sources. The packaging should be kept intact to prevent leakage, contamination and performance degradation; it should not be mixed with toxic, harmful, corrosive substances and strong oxidants. When taking, minimize the contact time with air, and seal the packaging immediately after use to avoid volatilization and contamination. It should be stored separately from other flammable and reactive chemicals, and the storage environment should be well-ventilated, equipped with explosion-proof electrical equipment to prevent static discharge[6].
Safety: It is a flammable liquid and irritant substance (GHS07, signal word: Warning), with hazard statement H226 (flammable liquid and vapor) and UN transport number UN1987 (Class 3, PG 3). It may cause skin and eye irritation, and may cause respiratory discomfort if inhaled. Its risk code is R16, and it has low acute toxicity, with no carcinogenicity reported by ACGIH, IARC or NTP. When handling, wear appropriate protective equipment (gloves, goggles, protective clothing), and operate in a well-ventilated environment, avoiding breathing vapor or mist, and preventing contact with skin and eyes. Keep away from heat sources, sparks, open flames and hot surfaces, prohibit smoking, use explosion-proof electrical, ventilation and lighting equipment, and use tools that do not produce sparks to prevent static discharge. In case of skin (or hair) contact, immediately remove all contaminated clothing and rinse the skin with water or take a bath; in case of eye contact, rinse carefully with water for several minutes (remove contact lenses if present and easy to do) and continue rinsing. In case of fire, use dry sand, dry chemicals or alcohol-resistant foam to extinguish the fire. This product is for industrial, pharmaceutical R&D and scientific research use only, not for direct human or veterinary use. Disposal should be consistent with federal, state, and local regulations[3][7].
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