Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
(1R,2R)-1,2-Cyclohexanedimethanol (CAS 65376-05-8) is a high-purity chiral diol, belonging to cycloaliphatic diol compounds. Its molecular formula is C?H??O? and molecular weight is 144.21 Da. It exists as a white to off-white crystalline solid or powder at room temperature, with a trans configuration of hydroxymethyl groups that endows it with unique conformational properties. It is mainly prepared through enantioselective synthesis and purification, and is widely used as a key chiral intermediate in pharmaceutical synthesis (such as the synthesis of atypical antipsychotic drug lurasidone), a monomer in polymer chemistry for producing polyesters and polyurethanes, and a precursor for specialty chemicals like surfactants and lubricants.
1. Physical Properties
White to off-white crystalline solid or powder, no obvious odor, slightly soluble in chloroform and methanol. It has a density of 1.004, melting point of 63.0 to 67.0 °C, boiling point of 270 °C, flash point of 129 °C, and a predicted pKa of 14.75±0.10; slightly sensitive to light and heat.
2. Chemical Properties
It is a chiral cycloaliphatic diol with a stable trans configuration of hydroxymethyl groups. It is stable under normal storage conditions, incompatible with strong oxidants, and prone to decomposition under extreme conditions. Its chiral structure makes it a valuable building block for synthesizing complex molecules, and it can participate in polymerization reactions as a monomer to enhance the flexibility and durability of polymers.
3. Storage & Safety Properties
Storage: Store at room temperature in a sealed, dry and dark place; avoid moisture, direct sunlight and strong oxidants; keep the packaging intact to prevent contamination and performance degradation. Safety: It is a non-hazardous substance with low toxicity, GHS07 hazard category and signal word "Warning". It may cause slight irritation; wear protective equipment (dust mask, safety glasses, gloves) during operation, ensure adequate ventilation, and avoid contact with skin, eyes and clothing. It is for pharmaceutical R&D, polymer synthesis and scientific research use only; dispose of according to relevant regulations.
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