Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Piperazine, 1-benzoyl-4-(1-oxopropyl)- (also known as 1-Benzoyl-4-propanoylpiperazine) is a key piperazine derivative. It has good chemical stability and modifiable molecular structure, which makes it a valuable intermediate widely used in pharmaceutical synthesis, especially in the development of novel therapeutic agents and new antibiotics.
Molecular Formula & Structure
Molecular Formula: C??H??N?O?
Physical Properties
- Appearance: White crystalline powder
- Storage Temperature: Recommended 2-8 °C
- Solubility: Soluble in water (24 mg/ml)
- Appearance: White solid precipitate (after reaction work-up)
Chemical Properties
- Molecular Weight: 246.30
- CAS Number: 314728-85-3 (confirmed)
- pKa: 0.08 ± 0.70 (predicted)
- Stability: Inherently chemically stable, with versatile modification potential
- Chemical Type: Piperazine derivative, with benzoyl group and propanoyl group substituted on the two nitrogen atoms of the piperazine ring respectively
- WGK Germany: 3
Synthesis Method
- Raw Materials: Piperazine, benzoyl chloride (or ethyl benzoate), propanoyl chloride (or related acylating agents)
- Reaction Principle: Stepwise N-acylation reaction of piperazine, first acylating to obtain 1-benzoylpiperazine, then performing the second acylation to introduce the propanoyl group, forming the target product.
- Reaction Steps: Synthesize 1-benzoylpiperazine first, then conduct the second acylation reaction, stir at room temperature after adding reagents, filter the precipitated solid, and purify by recrystallization to obtain the pure product.
Storage & Safety
- Storage: Sealed, stored in a cool, dry and light-proof container; recommended storage temperature 2-8 °C; avoid humidity, direct sunlight and heat spikes.
- Package: Moisture-resistant, light-proof container; suitable for lab-grade or industrial bulk packaging.
- Safety: Avoid contact with skin and mucous membranes; operate in a clean area and use clean dedicated tools to prevent cross-contamination.
- Hazard: No obvious flammable and explosive hazards; avoid long-term exposure to air and UV rays to prevent purity degradation.
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