Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Roxithromycin (CAS: 80214-83-1) is a semi-synthetic 14-membered macrolide antibiotic, derived from erythromycin via 9-position oximation modification. It has good acid stability and oral bioavailability, inhibiting bacterial protein synthesis to exert antibacterial activity. It is widely used in the treatment of infections caused by Gram-positive bacteria, anaerobic bacteria and atypical pathogens, and is also used as a pharmaceutical raw material compliant with USP and Chinese Pharmacopoeia standards.
Molecular Formula & Structure
Molecular Formula: C??H??N?O??
Physical Properties
- Appearance: White to off-white crystalline powder, odorless, slightly bitter, slightly hygroscopic
- Melting Point: 115–120 °C
- Density: ~1.18 g/cm3 (25 °C)
- Solubility: Slightly soluble in water, soluble in methanol, ethanol, acetone and chloroform; insoluble in hexane
- Optical Rotation: +82° to +88° (c=1, methanol, 25 °C)
- Thermal Stability: Stable under cool and dark conditions; decomposes at high temperature above 150 °C
Chemical Properties
- CAS Number: 80214-83-1 (confirmed)
- Chemical Type: Semi-synthetic macrolide antibiotic, erythromycin derivative
- Molecular Weight: 837.05
- Chemical Resistance: Stable in weak acid environment; unstable in strong acid and strong alkali conditions
- Antibacterial Activity: Inhibits bacterial ribosome 50S subunit protein synthesis, effective against Staphylococcus aureus, Streptococcus, Mycoplasma and Chlamydia
- Application Type: Pharmaceutical raw material, used in preparing tablets, dry suspensions and other formulations
Synthesis Method
- Raw Materials: Erythromycin thiocyanate, hydroxylamine hydrochloride, methoxyethoxymethyl chloride (MEMC), triethylamine, sodium methoxide, DMF, methanol[8]
- Synthesis Route: Two-step reaction – oximation of erythromycin to form erythromycin oxime, then etherification with MEMC to obtain roxithromycin[5][8]
- Reaction Steps: Dissolve raw materials, conduct oximation at 35–45 °C, then etherification at -10~-5 °C, followed by precipitation, washing, drying and purification to get the product[8]
Storage & Safety
- Storage: Sealed, cool, dry and dark place (15–25 °C, RH ≤60%); avoid moisture, sunlight and high temperature; shelf life 36 months
- Package: Moisture-proof, light-proof container (1 kg/bag or 25 kg/drum), compliant with GMP standards
- Safety: Avoid skin/eye contact and dust inhalation; wear PPE during operation; avoid contact with calcium-containing feeds or metal ions (Fe, Cu)
- Hazard: No obvious flammable and explosive hazards; thermal decomposition may release harmful gases; aqueous solution should be prepared and used immediately
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