Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Citalopram hydrobromide (CAS: 59729-32-7) is a highly selective serotonin (5-HT) reuptake inhibitor (SSRI), belonging to the bicyclic phthalate derivative class. It is a common oral antidepressant that exerts its therapeutic effect by inhibiting the reuptake of 5-HT in central nervous system neurons, thereby enhancing central 5-HT nerve function[3][4]. It is effective for both endogenous and non-endogenous depression, with mild and transient side effects, and is suitable for long-term treatment without affecting the heart conduction system, blood, liver or kidney systems[3][4]. It is widely used as a pharmaceutical raw material for preparing tablets, capsules and other formulations.
Molecular Formula & Structure
Molecular Formula: C??H??BrFN?O
Physical Properties
- Appearance: White crystalline powder, odorless, slightly bitter
- Melting Point: 182–188 °C
- Density: ~1.38 g/cm3 (25 °C, estimated)
- Solubility: Sparingly soluble in water (10 mM at 25 °C), soluble in ethanol (50 mM at 25 °C); insoluble in non-polar solvents
- Flash Point: 9 °C
- Stability: Stable under normal conditions; incompatible with strong oxidizing agents
- Form: Fine crystalline powder, no visible impurities
Chemical Properties
- CAS Number: 59729-32-7 (confirmed); EINECS: 261-890-6
- Chemical Type: Selective serotonin reuptake inhibitor (SSRI), antidepressant, bicyclic phthalate derivative
- Molecular Weight: 405.3
- Biological Activity: High selectivity for 5-HT reuptake (IC50 = 1.8 nM in rat brain synaptosomal preparations); little effect on noradrenaline (NA) and dopamine (DA) reuptake
- Chemical Characteristics: No obvious affinity for 5-HT receptors, GABA receptors, acetylcholine receptors or histamine receptors, reducing side effects such as dry mouth and sedation
- Application Type: Pharmaceutical raw material, used in the preparation of oral antidepressant formulations (tablets, capsules)
- Toxicity: Highly toxic; LD50 (intraperitoneal, rat): >10 mg/kg; LD50 (intraperitoneal, mouse): 16 mg/kg
Synthesis Method
- Raw Materials: 4-fluorobenzaldehyde, dimethylamine, acetonitrile, bromohydrin, magnesium turnings, and hydrobromic acid
- Synthesis Route: Multi-step synthesis involving Grignard reaction, condensation, cyclization and salt formation, with the key step being the construction of the bicyclic phthalate skeleton and introduction of the fluorine substituent
- Reaction Steps: Prepare Grignard reagent from magnesium turnings and bromohydrin, react with 4-fluorobenzaldehyde, condense with dimethylamine and acetonitrile, undergo cyclization reaction under controlled temperature, and finally form salt with hydrobromic acid, then purify by recrystallization to obtain the product
Storage & Safety
- Storage: Sealed, cool, dry and dark place; recommended storage temperature 2–8 °C; avoid moisture, sunlight, high temperature and contact with strong oxidants; store in a well-ventilated area; keep out of reach of children
- Package: Moisture-proof, light-proof and sealed pharmaceutical-grade container (1 kg/bottle or 25 kg/drum); UN number: 3249, packing group III
- Safety: Avoid skin, eye and clothing contact; do not breathe dust or vapor; wear appropriate PPE (protective gloves, goggles, face shield) during operation; wash hands thoroughly after operation; keep away from food, beverages and animal feedingstuffs
- Hazard: Flammable (flash point 9 °C); highly toxic if swallowed, inhaled or absorbed through skin; combustion produces toxic gases (nitrogen oxides, fluorides); avoid contact with alcohols, amines, alkalis and water-containing substances
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