Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
RU 58841 (CAS: 154992-24-2), also known as PSK-3841 or HMR-3841, is a non-steroidal anti-androgen belonging to the aryl hydantoin derivative class[3][4][5]. It exerts its biological activity by acting on androgen receptors rather than reducing the production of testosterone or dihydrotestosterone (DHT)[1]. Clinically, it is used for the treatment of acne and androgenetic alopecia (baldness), and it is also commercially available as a pharmaceutical and cosmetic raw material with good local activity and high safety.
Molecular Formula & Structure
Molecular Formula: C??H??F?N?O?
Physical Properties
- Appearance: White to off-white solid crystalline powder, no obvious odor.
- Melting Point: Not explicitly reported; stable under normal temperature conditions.
- Density: ~1.35 g/cm3 (25 °C, estimated based on molecular structure).
- Solubility: Insoluble in water; soluble in DMSO (73 mg/mL, 197.64 mM at 25 °C) and ethanol (73 mg/mL, 197.64 mM at 25 °C).
- Stability: Stable under sealed, cool and dark conditions; incompatible with strong oxidants and acidic reagents.
- Form: Fine crystalline powder, no visible impurities.
Chemical Properties
- CAS Number: 154992-24-2 (confirmed); DTXSID: 20165781.
- Chemical Type: Non-steroidal anti-androgen, aryl hydantoin derivative, pharmaceutical and cosmetic raw material.
- Molecular Weight: 369.34.
- Biological Activity: Targets androgen receptors specifically; effective in treating androgenetic alopecia and acne, with no obvious systemic side effects.
- Chemical Characteristics: Contains a hydantoin (five-membered nitrogen-containing heterocyclic) core structure, with trifluoromethyl and cyano substituents on the aromatic ring.
- Application Type: Pharmaceutical raw material for treating acne and baldness; also used in cosmetic formulations for hair growth.
- Toxicity: Low acute toxicity; specific LD50 data not publicly reported; non-irritating to normal skin at recommended concentrations.
Synthesis Method
- Raw Materials: 4-amino-2-(trifluoromethyl)benzonitrile, 4-bromo-1-butanol, 2-aminoisobutyrate hydrochloride, solid triphosgene (bis(trichloromethyl) carbonate), 1,4-dioxane.
- Synthesis Route: Three-step reaction involving substitution, isocyanation and cycloaddition; solid triphosgene is used to replace phosgene to improve safety, with a total yield of up to 50.75%.
- Reaction Steps: Firstly, react 4-bromo-1-butanol with 2-aminoisobutyrate hydrochloride to obtain an intermediate; then synthesize 3-trifluoromethyl-4-cyanophenyl isocyanate from 4-amino-2-(trifluoromethyl)benzonitrile and solid triphosgene; finally, perform cycloaddition reaction with the intermediate, and purify to obtain the product.
Storage & Safety
- Storage: Sealed, cool, dry and dark place; recommended storage temperature -20 °C (powder, 3 years) or -80 °C (dissolved in solvent, 1 year); avoid moisture, sunlight and high temperature.
- Package: Moisture-proof, light-proof and sealed container (1 g/bottle or 10 g/bottle for lab grade; 25 kg/drum for industrial grade).
- Safety: Avoid skin and eye contact; wear appropriate PPE (protective gloves, goggles) during operation; do not breathe dust; wash hands thoroughly after operation.
- Hazard: No obvious flammable and explosive hazards; thermal decomposition may release toxic gases (cyanides, fluorides); avoid contact with strong acids and oxidants.
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