Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
2-Chloro-5-chloromethylthiazole (CAS: 105827-91-6), abbreviated as CCMT, is an important heterocyclic organic compound belonging to the thiazole derivative class. It is a key intermediate for the synthesis of second-generation neonicotinoid insecticides such as thiamethoxam and clothianidin, and is also widely used in the synthesis of pharmaceutical raw materials such as ritonavir (an HIV inhibitor). It exists as white to light yellow crystals or crystalline powder at room temperature, with high reactivity and broad application prospects in the pesticide and pharmaceutical industries.
Molecular Formula & Structure
Molecular Formula: C?H?Cl?NS
Physical Properties
- Appearance: White to light yellow crystalline powder or lumps, with no obvious peculiar odor.
- Melting Point: 29–35 °C (typical range 30–31 °C).
- Density: ~1.503 g/cm3 (25 °C, predicted).
- Boiling Point: 268.6 ± 32.0 °C (predicted); 108–110 °C at 2.4 kPa (reduced pressure).
- Solubility: Insoluble in water; soluble in methanol, dichloromethane, chloroform, carbon tetrachloride and other organic solvents.
- Stability: Stable under proper storage conditions; heat-sensitive, easy to decompose when exposed to high temperature.
- Refractive Index: n??/D 1.571 (20 °C).
Chemical Properties
- CAS Number: 105827-91-6 (confirmed); MDL Number: MFCD01073549;
- Chemical Type: Thiazole derivative, organic intermediate, pesticide and pharmaceutical raw material.
- Molecular Weight: 168.04.
- pKa (Predicted): 0.19 ± 0.10.
- Chemical Characteristics: Contains thiazole ring (five-membered heterocyclic ring containing sulfur and nitrogen) and two chlorine-containing substituents, with high chemical reactivity.
- Application Type: Key intermediate for neonicotinoid insecticides (thiamethoxam, clothianidin) and pharmaceutical raw materials (ritonavir).
- Toxicity: Toxic by skin contact and ingestion; causes severe skin burns and eye damage; may cause skin allergic reactions; toxic to aquatic organisms with long-term effects.
Synthesis Method
- Raw Materials: 2-chloropropenyl isothiocyanate, chloroform, sulfuryl chloride (or chlorine, sulfonyl chloride).
- Synthesis Route: Addition-cyclization reaction using 2-chloropropenyl isothiocyanate as the main raw material, with chloroform as solvent and sulfuryl chloride as chlorinating agent.
- Reaction Steps: Add 2-chloropropenyl isothiocyanate and chloroform into a reaction flask, dropwise add sulfuryl chloride while maintaining the internal temperature at 30 °C; after dropping, react at room temperature for 2.5 hours (internal temperature rises to 36 °C); distill to remove solvent and residual sulfuryl chloride, dissolve the residue in dichloromethane, wash with sodium bicarbonate solution and water successively, dry, and distill under reduced pressure to obtain the product.
Storage & Safety
- Storage: Store in a sealed, cool, dry and dark place; recommended storage temperature 2–8 °C (or 0–10 °C); keep in inert atmosphere; avoid high temperature, heat, sparks and open flames.
- Package: Corrosion-resistant and sealed container (25 g/bottle, 100 g/bottle, 250 kg/plastic drum); UN number: 2922; packing group II; hazard class 8/6.1.
- Safety: Operate in a well-ventilated area; wear full PPE (chemical protective gloves, protective clothing, anti-corrosion goggles, dust-proof and gas-mask); avoid skin, eye contact and dust inhalation; wash hands thoroughly after operation.
- Hazard: Corrosive, toxic; may cause severe skin and eye burns; may cause skin allergies; toxic to aquatic organisms; thermal decomposition may produce harmful gases; avoid leakage into the environment.
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