Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
TRIFLUOROMETHYL SULFINYL CHLORIDE (CAS: 20621-29-8), also known as Trifluoromethanesulfinyl Chloride, is an important fluorinated organic compound with high reactivity and strong oxidizing properties. It is a key intermediate in the synthesis of pesticides, especially the insecticide fipronil, and is also widely used in the synthesis of pharmaceutical raw materials and other fine chemicals. As a versatile reagent in organic synthesis, it is famous for being a source of trifluoromethylsulfinyl radicals, which can participate in free radical reactions and introduce trifluoromethylsulfinyl groups into target molecules. It exists as a liquid at room temperature, is easy to volatilize, and needs strict handling due to its special chemical properties.
Molecular Formula & Structure
Molecular Formula: CClF?OS
Physical Properties
- Appearance: Colorless liquid; may be faintly colored under certain conditions, with no obvious peculiar odor
- Melting Point: Low, presenting as a liquid at room temperature and not easy to solidify under normal conditions
- Density: Approximately g/cm3 (room temperature)
- Boiling Point: Moderate, easy to volatilize at room temperature, decomposing slightly at higher temperatures
- Solubility: Insoluble in water, easy to hydrolyze when in contact with water; soluble in inert organic solvents
- Stability: Stable under dry and sealed conditions; easy to decompose when exposed to moisture or water; has certain lachrymatory properties
- Volatility: High, easy to volatilize at room temperature, requiring sealed storage to prevent leakage
Chemical Properties
- CAS Number: 20621-29-8 (confirmed); EINECS: Corresponding to Trifluoromethyl Sulfinyl Chloride; PubChem ID: Corresponding to Trifluoromethyl Sulfinyl Chloride
- Chemical Type: Fluorinated organic compound, organic intermediate, oxidizing reagent, pesticide intermediate
- Molecular Weight: Approximately 153
- Chemical Characteristics: Strong oxidizing property and high reactivity; contains trifluoromethyl and sulfinyl chloride groups, easy to undergo substitution and addition reactions; hydrolyzes when in contact with water
- Reactivity: Can be used as a trifluoromethylsulfinylating reagent, participating in various organic reactions such as cyclization and rearrangement; can react with various precursors to synthesize fluorine-containing compounds
- Application Type: Key intermediate for insecticides (fipronil); raw material for pharmaceutical and fine chemical synthesis; multifunctional reagent in organic synthesis
- Toxicity: Toxic by inhalation and skin contact; has lachrymatory properties, which can irritate eyes, skin and respiratory tract; may cause corrosion and burns to mucous membranes; harmful to the environment
Synthesis Method
- Raw Materials: Trifluoromethyl chloride (or trifluoroacetate potassium), sodium dithionite (or sulfur dioxide), thionyl chloride; alternatively, perchloromethyl mercaptan (for new synthesis routes)
- Synthesis Route: Mainly chemical synthesis, including two common routes: one is the reaction of trifluoromethyl chloride with sodium dithionite to generate trifluoromethyl sulfinate, then react with thionyl chloride to obtain the product; the other is the reaction of trifluoroacetate potassium with sulfur dioxide to generate trifluoromethyl sulfinate potassium, then react with thionyl chloride to produce the product; new routes can also be used to obtain the product through fluorination, oxidation and chlorination of perchloromethyl mercaptan
- Reaction Steps: Common synthesis process: Mix trifluoromethyl chloride with sodium dithionite for reaction to generate trifluoromethyl sulfinate, then add thionyl chloride as a chlorinating agent, control the reaction conditions, carry out chlorination reaction, and after the reaction is completed, obtain high-purity products through separation, purification and distillation steps; the new route process: take perchloromethyl mercaptan as raw material, first carry out fluorination reaction to obtain trifluoromethyl thiofluoro, then carry out oxidation reaction to generate trifluoromethyl sulfinyl fluoride, and finally carry out chlorination reaction to obtain the target product
Storage & Safety
- Storage: Store in a sealed, cool, dry and well-ventilated area; avoid moisture, water and high temperature; recommended storage temperature within a low to moderate range to reduce volatilization and prevent decomposition
- Package: Corrosive-resistant, airtight and anti-volatilization containers (various specifications); classified according to hazardous chemical standards; with clear safety warning labels and hazard classification marks
- Safety: Operate in a well-ventilated fume hood; wear full personal protective equipment (acid-resistant gloves, protective clothing, face shield, gas mask); avoid skin, eye contact and inhalation of volatile gas; wash thoroughly with water immediately after contact; avoid mixing with water, strong reducing agents and other incompatible substances
- Hazard: Flammable or combustible under certain conditions; has strong irritation and lachrymatory properties; corrosive to skin and mucous membranes; hydrolyzes when in contact with water to produce harmful substances; toxic to aquatic organisms and causes environmental pollution if leaked
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