Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Clozapine (CAS: 5786-21-0) is a second-generation antipsychotic drug with strong antipsychotic effects and few extrapyramidal reactions. It is mainly used for the treatment of refractory acute and chronic schizophrenia, mania, and other mental illnesses with excitement and restlessness as the main symptoms. It is a yellowish crystalline powder, widely used in clinical practice and pharmaceutical research, and has been included in the WHO Model List of Essential Medicines.
Molecular Formula & Structure
Molecular Formula: C??H??ClN?
Physical Properties
- Appearance: Yellowish crystalline powder; odorless
- Melting Point: Undetermined specific range
- Density: Approximately g/cm3 (room temperature)
- Boiling Point: Undetermined specific value
- Solubility: Easily soluble in chloroform, soluble in ethanol, almost insoluble in water
- Stability: Stable under normal storage conditions; avoid direct sunlight, high temperature and moisture; sensitive to light and may discolor when exposed to light
- Optical Property: No specific optical rotation related specifications
Chemical Properties
- CAS Number: 5786-21-0 (confirmed); MDL Number: MFCD00050020
- Chemical Type: Second-generation antipsychotic, pharmaceutical raw material, clinical drug, organic heterocyclic compound
- Molecular Weight: Approximately
- Chemical Characteristics: Organic heterocyclic compound containing chlorine and piperazine groups; has high affinity for multiple receptors (dopamine subtypes, 5-HT subtype, etc.), which is related to its strong antipsychotic effect and few extrapyramidal reactions.
- Application Type: Clinical antipsychotic (treating various subtypes of schizophrenia, mania); pharmaceutical raw material for preparing tablets and injections; pharmaceutical research reagent
- Toxicity: Moderate toxicity; may cause adverse reactions such as drowsiness, tachycardia, salivation, and rare granulocytopenia or epilepsy; contraindicated in patients allergic to clozapine, with obvious central nervous system depression and myeloproliferative disorders.
Synthesis Method
- Raw Materials: o-Chloronitrobenzene (main raw material); auxiliary reagents such as zinc powder, ammonium chloride, formic acid, acetic anhydride, thionyl chloride, and hexamethylenediamine
- Synthesis Route: Taking o-chloronitrobenzene as the raw material, it is first reduced and formylated to obtain an intermediate, then chlorinated, and finally cyclized with hexamethylenediamine to obtain the product; the operation is simple and the cost is low.
Storage & Safety
- Storage: Sealed, cool, dry and ventilated; store at room temperature; avoid direct sunlight, high temperature and moisture; protect from light to prevent discoloration and deterioration.
- Package: Sealed, light-proof containers with clear labels; comply with pharmaceutical standards, indicating product name, CAS number, specifications and validity period
- Safety: Operate in a ventilated environment; wear protective equipment (gloves, goggles); avoid skin/eye contact and ingestion; wash thoroughly with water immediately after contact
- Hazard: Non-flammable; may cause environmental pollution if leaked in large quantities; avoid mixing with incompatible substances; keep away from children and pets to prevent accidental ingestion.
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