Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline (CAS: 30356-07-1), also known as (S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline, is an important chiral organic heterocyclic compound. It is mainly used as a pharmaceutical intermediate, particularly serving as an impurity reference substance for dextromethorphan, and also plays a key role in the synthesis of fine chemicals and chiral drug research. It is a high-purity chiral compound with stable chemical properties under proper storage conditions.
Molecular Formula & Structure
Molecular Formula: C??H??NO
Physical Properties
- Appearance: Undetermined specific appearance; typically a solid or liquid consistent with similar heterocyclic compounds
- Melting Point: Undetermined specific range
- Density: Approximately g/cm3 (room temperature)
- Boiling Point: Undetermined specific value
- Solubility: Soluble in common organic solvents; solubility in water is undetermined
- Stability: Stable under normal storage conditions; avoid direct sunlight, high temperature and moisture to prevent decomposition
- Optical Property: Has specific optical rotation due to its chiral center (S-configuration), with related specifications depending on the product grade
Chemical Properties
- CAS Number: 30356-07-1 (confirmed)
- Chemical Type: Chiral organic heterocyclic compound, pharmaceutical intermediate, impurity reference substance, fine chemical raw material
- Molecular Weight: Approximately 257
- Chemical Characteristics: Chiral compound containing isoquinoline ring and methoxyphenylmethyl group; has typical heterocyclic compound reactivity, and its chiral configuration endows it with special application value in asymmetric synthesis and drug research.
- Application Type: Impurity reference substance for dextromethorphan; pharmaceutical intermediate for chiral drug synthesis; raw material for fine chemical synthesis; research reagent for chiral chemistry
- Toxicity: Undetermined specific toxicity; should be handled with proper protective measures to avoid skin, eye contact and ingestion; follow general chemical safety operation specifications.
Synthesis Method
- Raw Materials: Appropriate isoquinoline derivatives, 4-methoxybenzyl chloride (or related derivatives), and chiral catalysts or auxiliary reagents for asymmetric synthesis
- Synthesis Route: Prepared through asymmetric synthesis or chiral resolution methods; the isoquinoline ring is first hydrogenated to obtain octahydroisoquinoline intermediate, then connected with 4-methoxyphenylmethyl group, and finally chiral purification is performed to obtain the target product (S-configuration).
Storage & Safety
- Storage: Sealed, cool, dry and ventilated; store at room temperature; avoid direct sunlight, high temperature and moisture; protect from light to maintain its stability and chiral purity.
- Package: Sealed containers with clear labels; comply with pharmaceutical intermediate or reference substance standards, indicating product name, CAS number, configuration and purity.
- Safety: Operate in a ventilated environment; wear protective equipment (gloves, goggles); avoid skin/eye contact and ingestion; wash thoroughly with water immediately after contact.
- Hazard: Non-flammable under normal conditions; may cause environmental pollution if leaked in large quantities; avoid mixing with incompatible substances such as strong oxidants and strong acids.
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