Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
5-Chloro-2-pentanone (CAS: 5891-21-4), also known as 5-Chloropentan-2-one, 1-Chloro-4-pentanone or 3-Chloropropyl methyl ketone, is a valuable bifunctional organic compound. It is a clear liquid with a ketone carbonyl and a reactive chloro alkyl group, serving as a key intermediate in organic synthesis, pharmaceutical and agrochemical production. It is widely used in the synthesis of heterocyclic compounds, pharmaceutical raw materials such as chloroquine phosphate, and spice intermediates, and is also applied in laboratory research and scalable synthesis of complex molecular architectures.
Molecular Formula & Structure
Molecular Formula: C?H?ClO
Physical Properties
- Appearance: Colorless to brown clear liquid at room temperature
- Melting Point: Undetermined specific range
- Density: Approximately 1.05 g/cm3 (room temperature)
- Boiling Point: Approximately 106 °C (under specific pressure conditions)
- Solubility: Soluble in common organic solvents; solubility in water is undetermined
- Stability: Stable under proper storage conditions; unstable when exposed to air and high temperature, usually stabilized with potassium carbonate; avoid air, heating and direct sunlight
- Optical Property: No specific optical rotation related specifications
Chemical Properties
- CAS Number: 5891-21-4 (confirmed); MDL Number: MFCD00001008; EINECS Number: 227-565-8
- Chemical Type: Bifunctional organic compound, organic synthesis intermediate, pharmaceutical intermediate, spice intermediate, laboratory research reagent
- Molecular Weight: Approximately 121
- Chemical Characteristics: Contains ketone carbonyl and chloro alkyl group, with typical reactivity of halogenated ketones; prone to nucleophilic substitution reactions, reduction reactions and derivatization reactions, and can be used for chain elongation and ring-closure reactions in organic synthesis.
- Application Type: Intermediate for pharmaceutical synthesis (e.g., chloroquine phosphate); spice intermediate; raw material for heterocyclic compound synthesis (e.g., piperazines, morpholines); laboratory research reagent for studying reaction kinetics of halogenated ketones.
- Toxicity: Harmful if swallowed; has irritation to skin, eyes and respiratory tract; strictly for research and industrial use, not for human or veterinary use.
Synthesis Method
- Raw Materials: 2-Methylfuran (main raw material), hydrogen, hydrochloric acid, palladium-carbon catalyst (or other hydrogenation catalysts); alternatively, acetyl n-propanol and chlorinating reagents.
- Synthesis Route: The main route involves hydrogenating 2-methylfuran to obtain 2-methyl-4,5-dihydrofuran under the action of a hydrogenation catalyst, then conducting ring-opening chlorination reaction with hydrochloric acid to obtain the product; it can also be prepared by chlorinating acetyl n-propanol; the product is refined by rectification to improve purity.
Storage & Safety
- Storage: Sealed, refrigerated (0-10°C) and stored under inert gas; kept in a cool, dry and well-ventilated environment; avoid air, heating, direct sunlight and moisture to maintain stability.
- Package: Sealed containers with clear labels; comply with organic intermediate standards, indicating product name, CAS number, purity and storage requirements; usually stabilized with potassium carbonate.
- Safety: Operate in a ventilated environment; wear protective equipment (gloves, goggles, protective mask); avoid skin, eye contact and ingestion; no eating, drinking or smoking during operation; wash thoroughly with water immediately after contact; use explosion-proof electrical, ventilation and lighting equipment.
- Hazard: Flammable liquid and vapor; harmful if swallowed; may cause environmental pollution if leaked in large quantities; avoid mixing with incompatible substances; use dry sand, dry powder or alcohol-resistant foam for fire fighting.
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