Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Cyclazodone (CAS: 14461-91-7), also known as Cyclopropyl Pemoline, 2-(Cyclopropylamino)-5-phenyl-1,3-oxazol-4(5H)-one or 5-Phenyl-2-cyclopropylamino-4-oxazolinone, is a synthetic central nervous system stimulant belonging to the substituted aminorex and 4-oxazolidinone chemical classes. First developed by the American Cyanamid Company in the 1960s, it is a close derivative of pemoline, with a more potent pharmacological profile and fewer adverse effects compared to its parent compound. It is primarily used as a research reagent, certified reference material for analytical purposes, and in laboratory studies exploring cognitive function and neurotransmitter regulation, and is strictly for research use only, not for human or veterinary applications.
Molecular Formula & Structure
Molecular Formula: C??H??N?O?
Physical Properties
- Appearance: White to off-white solid powder at room temperature
- Melting Point: Approximately 139–140 °C (solvated in ethanol and hexane)
- Density: Approximately 1.40 g/cm3 (predicted, room temperature)
- Boiling Point: Approximately 334.8 °C (predicted, under standard pressure)
- Solubility: Sparingly soluble in chloroform, slightly soluble in DMSO and methanol; solubility in water is undetermined
- Stability: Stable under proper storage conditions; demonstrates long-term stability (minimum 3 years) when stored as recommended; avoid direct sunlight, high temperature and moisture
- Optical Property: Exists as a racemic mixture (RS-configuration), no specific optical rotation related specifications for the racemate
Chemical Properties
- CAS Number: 14461-91-7 (confirmed); PubChem CID: 26701; UNII: O8U55ZRL9K
- Chemical Type: Synthetic stimulant, 4-oxazolidinone derivative, pharmaceutical reference material, research reagent, psychoactive compound
- Molecular Weight: Approximately 216.24
- Chemical Characteristics: Organic heterocyclic compound containing oxazolone and cyclopropylamino groups; as a derivative of pemoline, it exhibits dopaminergic and norepinephrinergic stimulating activity, with minimal sympathomimetic effects and lower cardiotoxicity compared to amphetamines; prone to typical organic reactions such as amide formation and heterocyclic ring derivatization.
- Application Type: Certified reference material for analytical calibration; laboratory research reagent for studying cognitive function, neurotransmitter release and stimulant pharmacology; used in forensics and toxicology analysis; also explored for potential nootropic properties in preclinical research.
- Toxicity: Classified as acutely toxic (oral, category 3); exhibits hepatotoxicity potential (inherited from pemoline); LD?? (mouse, intraperitoneal) is approximately 81 mg/kg; may cause irritation to skin and eyes; strictly for research use, not for human consumption.
Synthesis Method
- Raw Materials: α-Chlorophenyl acetyl chloride and 1-cyclopropylurea (main raw materials); sodium ethoxide (catalyst/condensing agent); alternatively, pemoline and chlorocyclopropane (for alkylation reaction).
- Synthesis Route: The main route involves reacting α-chlorophenyl acetyl chloride with 1-cyclopropylurea to form an amide intermediate, which then undergoes cyclization under the action of sodium ethoxide to form the target product; alternatively, it can be prepared by alkylating pemoline with chlorocyclopropane; the product is purified by recrystallization or chromatographic methods to achieve high purity.
Storage & Safety
- Storage: Sealed in amber glass containers; store at 2–8 °C (or ≤25 °C) in a cool, dry, dark and well-ventilated environment; avoid direct sunlight, high temperature, moisture and incompatible substances; equilibrate to room temperature before opening to prevent moisture absorption.
- Package: Sealed, light-proof containers with clear labels; comply with reference material and research reagent standards, indicating product name, CAS number, purity, batch number and storage requirements; available in powder or liquid form.
- Safety: Operate in a ventilated environment; wear full personal protective equipment (gloves, goggles, protective mask); avoid skin, eye contact and ingestion; do not eat, drink or smoke during operation; in case of contact, rinse thoroughly with large amounts of water and seek medical attention if necessary.
- Hazard: Non-flammable under normal conditions; may emit irritant fumes during combustion; acutely toxic if swallowed; may cause environmental pollution if leaked in large quantities; avoid mixing with strong oxidants and acidic substances; use water spray, dry chemical, foam or carbon dioxide for fire fighting.
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