Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Bis(2-chloroethyl)amine hydrochloride (CAS: 821-48-7), also known as Bis(β-chloroethyl)amine hydrochloride, 2,2'-Dichloro-diethylamine hydrochloride or Dichloroethylamine hydrochloride, is a common organic chloride containing two chloroethyl groups. It is a white to off-white solid powder with high reactivity, serving as a key intermediate in organic synthesis, pharmaceutical, pesticide, dyestuff and surfactant industries. It is widely used in the synthesis of various organic derivatives, pharmaceutical raw materials, pesticides and dyes, and also acts as a research reagent for laboratory organic reaction studies, with broad application potential in fine chemical fields.
Molecular Formula & Structure
Molecular Formula: C?H??Cl?N
Physical Properties
- Appearance: White to off-white solid powder at room temperature
- Melting Point: Approximately 212–214 °C (lit.)
- Density: Approximately 1.125 g/cm3 (room temperature)
- Boiling Point: Approximately 204.2 °C at 760 mmHg
- Solubility: Soluble in water; soluble in common organic solvents
- Stability: Stable under normal temperature and pressure; should be sealed and protected from light during storage; avoid contact with oxidants and moisture to prevent decomposition
- Optical Property: No specific optical rotation related specifications
Chemical Properties
- CAS Number: 821-48-7 (confirmed); EINECS Number: 212-479-5
- Chemical Type: Organic chloride, organic amine hydrochloride, fine chemical raw material, pharmaceutical intermediate, pesticide intermediate, dyestuff intermediate
- Molecular Weight: Approximately 178.49
- Chemical Characteristics: Organic compound containing two chloroethyl groups and an amino group (in hydrochloride form); has typical reactivity of alkyl chlorides and amines, prone to nucleophilic substitution reactions with various ligands to generate diverse derivatives; the chloroethyl groups are highly reactive, making it an important building block for organic synthesis.
- Application Type: Intermediate for pharmaceutical synthesis; raw material for pesticide and dyestuff production; intermediate for surfactant synthesis; laboratory research reagent for organic reaction studies; also used in surface treatment fields.
- Toxicity: Has certain toxicity and irritation; may cause irritation to skin, eyes and respiratory tract; harmful if swallowed or inhaled; should be handled with proper protective measures; strictly follow safety operation specifications during use.
Synthesis Method
- Raw Materials: Diethanolamine (main raw material); thionyl chloride or hydrochloric acid (chlorinating reagent); appropriate solvents and catalysts for the chlorination reaction.
- Synthesis Route: The main route involves chlorinating diethanolamine with thionyl chloride (or hydrochloric acid) to replace the hydroxyl groups with chlorine atoms, forming the target product; the reaction is carried out under controlled temperature conditions, and the product is purified by recrystallization or filtration to achieve high purity.
Storage & Safety
- Storage: Sealed in airtight containers; store in a cool, dry and well-ventilated environment; avoid direct sunlight, high temperature, moisture and contact with oxidants; keep away from fire sources and heat sources.
- Package: Sealed, moisture-proof containers with clear labels; comply with fine chemical and intermediate standards, indicating product name, CAS number, purity and storage requirements; available in solid powder form.
- Safety: Operate in a well-ventilated environment; wear full personal protective equipment (gloves, goggles, protective mask); avoid skin, eye contact and ingestion; do not eat, drink or smoke during operation; in case of contact, rinse thoroughly with large amounts of water and seek medical attention if necessary.
- Hazard: Non-flammable under normal conditions; may emit toxic and irritant fumes when heated or burned; may cause environmental pollution if leaked in large quantities; avoid mixing with strong oxidants; use dry sand, dry chemical or carbon dioxide for fire fighting.
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